Results 31 to 40 of about 89,922 (309)

Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei. [PDF]

, 2009
Genetic manipulation in African trypanosomes typically relies upon electroporation with chromosomal integration of DNA constructs by homologous recombination.
Glover, Lucy, Horn, David, Horn, David; id_orcid   +2 more
core   +1 more source

Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. [PDF]

, 2012
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been
Guan, Yinghua, Rajendran, Anbazhagan, Jagesh V. Shah (116400), Anyong Xie (116396), Gunnar Schotta (116394), Anbazhagan Rajendran (116388), Yinghua Guan (116385), Anyong Xie, Yinghua Guan, Ralph Scully, Hartlerode, Andrea J., Andrea J Hartlerode, Anbazhagan Rajendran, Gunnar Schotta, Andrea J. Hartlerode, Jagesh V. Shah, Jagesh V Shah, Andrea J. Hartlerode (116383), Ralph Scully (116402), Xie, Anyong, Shah, Jagesh, Ura, Kiyoe, Kiyoe Ura (116391), Scully, Ralph, Kiyoe Ura, Schotta, Gunnar, Shah, Jagesh V.   +26 more
core   +1 more source

All paired up with no place to go: pairing, synapsis, and DSB formation in a balancer heterozygote. [PDF]

PLoS Genetics, 2005
The multiply inverted X chromosome balancer FM7 strongly suppresses, or eliminates, the occurrence of crossing over when heterozygous with a normal sequence homolog.
Wei J Gong, Kim S McKim, R Scott Hawley
doaj   +2 more sources

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]

, 2012
Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Caroline A. Austin, Graham H. Jackson, Nicholas J. Morris, Zbyslaw Sondka, Tainer, JA, Padget, Kay, Simon J. Cockell, Curtis, H, Cockell, SJ, Curtis, Hannah, Sondka, Zbyslaw, Austin, CA, John A. Tainer, Cowell, IG, Austin, Caroline, Padget, K, Morris, Nicholas, Moiani, Davide, Cowell, Ian, Ian G. Cowell, Sondka, Z, Lee, KC, Tainer, John, Jackson, Graham, Kay Padget, Moiani, D, Lee, Ka Cheong, Jackson, GH, Ka Cheong Lee, Davide Moiani, Hannah Curtis, Morris, NJ, Cockell, Simon   +32 more
core   +1 more source

double‐strand break formation

, 2023
International audienceMeiotic recombination is initiated by the formation of DNA double‐strand breaks (DSBs), essential for fertility and genetic diversity.
Bernard de Massy, Kadlec, Jan, Aline Le Roy, Boeri Erba, Elisabetta, Gabel, Frank, Ariadna B Juarez‐Martinez, Le Roy, Aline, Laroussi, Hamida, Elisabetta Boeri Erba, Jan Kadlec, Frank Gabel, Hamida Laroussi, Juarez-Martinez, Ariadna, de Massy, Bernard   +13 more
core   +1 more source

Human RecQ Helicases in DNA Double-Strand Break Repair

Frontiers in Cell and Developmental Biology, 2021
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and animals. These helicases play important roles in multiple cellular functions, including DNA replication, transcription, DNA repair, and telomere maintenance.
Huiming Lu, Anthony J. Davis
doaj   +1 more source

DNA Double-Strand Breaks [PDF]

The Journal of Experimental Medicine, 2002
The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNA double-strand breaks (DSBs). As AID is capable of deaminating deoxy-cytidine (dC) to deoxy-uracil (dU), it might induce nicks (single strand DNA breaks) and ...
Linda Bross, Masamichi Muramatsu, Kazuo Kinoshita, Tasuku Honjo, Heinz Jacobs   +4 more
openaire   +1 more source

The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair.

PLoS Genetics, 2010
DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR), which can involve Holliday junction (HJ) intermediates that are ultimately resolved by nucleolytic enzymes.
Aymeric P Bailly, Alasdair Freeman, Julie Hall, Anne-Cécile Déclais, Arno Alpi, David M J Lilley, Shawn Ahmed, Anton Gartner   +7 more
doaj   +1 more source

Application of Pulsed Field Gel Electrophoresis to Determine γ-ray-induced Double-strand Breaks in Yeast Chromosomal Molecules [PDF]

, 1993
The frequency of DNA double-strand breaks (dsb) was determined in yeast cells exposed to γ-rays under anoxic conditions. Genomic DNA of treated cells was separated by pulsed field gel electrophoresis, and two different approaches for the evaluation of ...
Beisker, W., Eckardt-Schupp, F., Kellerer, Albrecht M., Eckard-Schupp, F., Friedl, A.A., Kellerer, A.M., Hahn, K.R., Friedl, Anna A., Hahn, K.   +8 more
core   +1 more source

Defects in DNA double‐strand break repair resensitize antibiotic‐resistant Escherichia coli to multiple bactericidal antibiotics

MicrobiologyOpen, 2022
Antibiotic resistance is becoming increasingly prevalent amongst bacterial pathogens and there is an urgent need to develop new types of antibiotics with novel modes of action.
Sarah A. Revitt‐Mills, Elizabeth K. Wright, Madaline Vereker, Callum O'Flaherty, Fairley McPherson, Catherine Dawson, Antoine M. vanOijen, Andrew Robinson   +7 more
doaj   +1 more source