Results 21 to 30 of about 89,922 (309)

Resection and repair of a Cas9 double-strand break at CTG trinucleotide repeats induces local and extensive chromosomal deletions.

PLoS Genetics, 2020
Microsatellites are short tandem repeats, ubiquitous in all eukaryotes and represent ~2% of the human genome. Among them, trinucleotide repeats are responsible for more than two dozen neurological and developmental disorders.
Valentine Mosbach, David Viterbo, Stéphane Descorps-Declère, Lucie Poggi, Wilhelm Vaysse-Zinkhöfer, Guy-Franck Richard   +5 more
doaj   +1 more source

Specificity of end resection pathways for double-strand break regions containing ribonucleotides and base lesions

Nature Communications, 2020
DNA double-strand break repair by homologous recombination initiates with nucleolytic resection of the 5’ DNA strand at the break ends. Here, the authors reveal that the lesion context influences the action and efficiency of the long range resection ...
James M. Daley, Nozomi Tomimatsu, Grace Hooks, Weibin Wang, Adam S. Miller, Xiaoyu Xue, Kevin A. Nguyen, Hardeep Kaur, Elizabeth Williamson, Bipasha Mukherjee, Robert Hromas, Sandeep Burma, Patrick Sung   +12 more
doaj   +1 more source

Chromatin Ubiquitination Guides DNA Double Strand Break Signaling and Repair

Frontiers in Cell and Developmental Biology, 2022
Chromatin is the context for all DNA-based molecular processes taking place in the cell nucleus. The initial chromatin structure at the site of the DNA damage determines both, lesion generation and subsequent activation of the DNA damage response (DDR ...
Ksenia G. Kolobynina, Alexander Rapp, M. Cristina Cardoso   +2 more
doaj   +1 more source

DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes. [PDF]

, 2013
Antigenic variation in African trypanosomes requires monoallelic transcription and switching of variant surface glycoprotein (VSG) genes. The transcribed VSG, always flanked by '70 bp'-repeats and telomeric-repeats, is either replaced through DNA double ...
Glover, Lucy, Horn, David, Horn, David; id_orcid, Lucy Glover (24966), Sam Alsford, David Horn (24969), Alsford, Sam, Lucy Glover, Sam Alsford (24967), David Horn   +9 more
core   +1 more source

DNA double-strand break repair in mammals

Journal of Radiation and Cancer Research, 2017
Failure in repair of DNA double-strand breaks (DSBs) could result in various disorders in mammals including cancer. Among various exogenous agents, radiation is one of the primary causes for induction of DSBs.
Monica Pandey, Sathees C Raghavan
doaj   +1 more source

Double‐strand DNA break repair: molecular mechanisms and therapeutic targets

MedComm, 2023
Double‐strand break (DSB), a significant DNA damage brought on by ionizing radiation, acts as an initiating signal in tumor radiotherapy, causing cancer cells death.
Jinpeng Tan, Xingyao Sun, Hongling Zhao, Hua Guan, Shanshan Gao, Ping‐Kun Zhou   +5 more
doaj   +1 more source

The Mechanism of Radiosensitization by YM155, a Novel Small Molecule Inhibitor of Survivin Expression, is Associated with DNA Damage Repair

Cellular Physiology and Biochemistry, 2015
Background/Aims: Survivin, a member of the inhibitor of apoptosis protein family, is an attractive target for cancer therapy. We investigated the effects of YM155, a small molecule inhibitor of survivin expression, on the radiosensitivity of human non ...
Songliu Hu, Songbin Fu, Xiangying Xu, Lin Chen, Jianyu Xu, Bin Li, Yuanyuan Qu, Hongyang Yu, Shan Lu, Wenxin Li   +9 more
doaj   +1 more source

Pre‐rRNA Facilitates TopBP1‐Mediated DNA Double‐Strand Break Response

Advanced Science, 2023
In response to genotoxic stress‐induced DNA damage, TopBP1 mediates ATR activation for signaling transduction and DNA damage repair. However, the detailed molecular mechanism remains elusive.
Di Xin, Xiaochen Gai, Yidi Ma, Zexing Li, Qilin Li, Xiaochun Yu   +5 more
doaj   +1 more source

Multi-scale cellular imaging of DNA double strand break repair [PDF]

, 2023
Live-cell and high-resolution fluorescence microscopy are powerful tools to study the organization and dynamics of DNA double-strand break repair foci and specific repair proteins in single cells.
Tim Heemskerk, Heemskerk, Tim, Essers, Jeroen, Kanaar, Roland, Jeroen Essers, Paul, Maarten W.; id_orcid, Roland Kanaar, Gerarda van de Kamp, Maarten W. Paul, van de Kamp, Gerarda   +9 more
core   +1 more source

SAW1 is increasingly required to recruit Rad10 as SSA flap-length increases from 20 to 50 bases in single-strand annealing in S. cerevisiae

Biochemistry and Biophysics Reports, 2021
SAW1 is required by the Rad1-Rad10 nuclease for efficient removal of 3′ non-homologous DNA ends (flaps) formed as intermediates during two modes of double-strand break repair in S.
Rowen Jane Odango, Juan Camberos, Fred Erick Fregoso, Paula L. Fischhaber   +3 more
doaj   +1 more source