Results 51 to 60 of about 55,108 (306)

Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy [PDF]

, 2014
BRCA1, a key factor in homologous recombination repair may also regulate base excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of ATM and DNA-PKcs could be a promising strategy in breast cancer.
Seedhouse, Claire, Russell, R, Moseley, P, Arora, A., Agarwal, D., Russell, R., Chan, Stephen, Green, A, Albarakati, N, Rakha, E.A., Abdel-Fatah, TMA, Caldas, C, Ellis, IO, Moseley, P., Rakha, Emad A., Albarakati, Nada, Doherty, Rachel, Chan, S., Perry, Christina, Seedhouse, C, Alsubhi, N., Ball, G., Moseley, Paul, Agarwal, D, Perry, C., Arora, Arvind, Alsubhi, N, Doherty, R, Arora, A, Russell, Roslin, Ball, G, Albarakati, N., Green, Andrew, Ball, Graham, Abdel-Fatah, Tarek M.A., Rakha, EA, Caldas, Carlos, Caldas, C., Ellis, I.O., Alsubhi, Nouf, Agarwal, Devika, Abdel-Fatah, T.M.A., Seedhouse, C., Chan, S, Doherty, R., Madhusudan, Srinivasan, Perry, C, Madhusudan, S, Green, A., Madhusudan, S., Ellis, Ian O.   +50 more
core   +1 more source

RNA-mediated double-strand break repair by end-joining mechanisms

Nature Communications
Double-strand breaks (DSBs) in DNA are challenging to repair. Cells employ at least three DSB-repair mechanisms, with a preference for non-homologous end joining (NHEJ) over homologous recombination (HR) and microhomology-mediated end joining (MMEJ ...
Youngkyu Jeon, Yilin Lu, Margherita Maria Ferrari, Tejasvi Channagiri, Penghao Xu, Chance Meers, Yiqi Zhang, Sathya Balachander, Vivian S. Park, Stefania Marsili, Zachary F. Pursell, Nataša Jonoska, Francesca Storici   +12 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Global and Local Manipulation of DNA Repair Mechanisms to Alter Site-Specific Gene Editing Outcomes in Hematopoietic Stem Cells

Frontiers in Genome Editing, 2020
Monogenic disorders of the blood system have the potential to be treated by autologous stem cell transplantation of ex vivo genetically modified hematopoietic stem and progenitor cells (HSPCs). The sgRNA/Cas9 system allows for precise modification of the
Elizabeth K. Benitez, Anastasia Lomova Kaufman, Lilibeth Cervantes, Danielle N. Clark, Paul G. Ayoub, Shantha Senadheera, Kyle Osborne, Julie M. Sanchez, Ralph Valentine Crisostomo, Xiaoyan Wang, Nina Reuven, Yosef Shaul, Roger P. Hollis, Zulema Romero, Donald B. Kohn   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition [PDF]

, 2013
© 2013 Yasaei et al.; licensee BioMed Central Ltd.This article has been made available through the Brunel Open Access Publishing Fund.Telomeres, the physical ends of chromosomes, play an important role in preserving genomic integrity.
Slijepcevic, P, Yaghoub Gozaly-Chianea, Yasaei, H, Predrag Slijepcevic, Hemad Yasaei, Gozaly-Chianea, Y   +5 more
core   +1 more source

Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development

Cell Reports, 2016
Error-prone repair of DNA double-strand breaks (DSBs) has been postulated to occur through classical non-homologous end joining (NHEJ) in systems ranging from nematode somatic tissues to zebrafish embryos.
Summer B. Thyme, Alexander F. Schier
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining [PDF]

Proceedings of the National Academy of Sciences, 2010
Given its significant role in the maintenance of genomic stability, histone methylation has been postulated to regulate DNA repair. Histone methylation mediates localization of 53BP1 to a DNA double-strand break (DSB) during homologous recombination repair, but a role in DSB repair by nonhomologous end-joining (NHEJ) has not been defined.
Sheema, Fnu, Elizabeth A, Williamson, Leyma P, De Haro, Mark, Brenneman, Justin, Wray, Montaser, Shaheen, Krishnan, Radhakrishnan, Suk-Hee, Lee, Jac A, Nickoloff, Robert, Hromas   +9 more
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source