Results 61 to 70 of about 55,108 (306)

Artemis over-expression and radiosensitivity in human cell lines [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The cellular radiosensitivity of two fibroblast cell lines derived from a breast cancer patient that “over-reacted” to radiotherapy (84BR) and a patient ...
Ulus-Senguloglu, Gonul
core  

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

, 2013
hSSB1 is a recently discovered single-stranded DNA binding protein that is essential for efficient repair of DNA double-strand breaks (DSBs) by the homologous recombination pathway.
Bain, Amanda, Khanna, Kum Kum, Menon, Dinoop, White, Malcolm F., Richard, Derek J., Urquhart, Aaron J., Bolderson, Emma, Cubeddu, Liza   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analysis of telomere maintenance in artemis defective human cell lines [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomeres are physical ends of chromosomes consisting of (TTAGGG)n DNA sequence and a specialized set of proteins that protect chromosomal ends from ...
Yasaei, Hemad
core  

Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA [PDF]

, 2011
How tightly packed chromatin is thoroughly inspected for DNA damage is one of the fundamental unanswered questions in biology. In particular, the effective excision of carcinogenic lesions caused by the ultraviolet (UV) radiation of sunlight depends on ...
Naegeli, H, Nina Kaczmarek, Andreas Glas, Glas, Andreas, Carell Thomas, Glas, A, Carell, Thomas, Fei Jia, Kaczmarek Nina, Glas Andreas, Jia Fei, Carell, T, Andreas Luch, Naegeli Hanspeter, Fei, Jia, Naegeli, Hanspeter, Luch Andreas, Kaczmarek, Nina, Thomas Carell, Hanspeter Naegeli, Luch, A, Luch, Andreas, Fei, J, Kaczmarek, N   +23 more
core   +1 more source

Decline of DNA damage response along with myogenic differentiation

Life Science Alliance
In postmitotic myotubes, DNA repair processes such as Base Excision Repair, and Non-Homologous End Joining are weakened compared with the proliferative precursors myoblasts. DNA integrity is incessantly confronted to agents inducing DNA lesions.
Haser H Sutcu, Phoebe Rassinoux, Lise-Marie Donnio, Damien Neuillet, François Vianna, Olivier Gabillot, Pierre-Olivier Mari, Céline Baldeyron, Giuseppina Giglia-Mari   +8 more
doaj   +1 more source

HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression

Cell Reports, 2023
Summary: B cells generate functionally different classes of antibodies through class-switch recombination (CSR), which requires classical non-homologous end joining (C-NHEJ) to join the DNA breaks at the donor and acceptor switch (S) regions.
Ahmed M. Refaat, Mikiyo Nakata, Afzal Husain, Hidetaka Kosako, Tasuku Honjo, Nasim A. Begum   +5 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells [PDF]

, 2009
© 2009 by The American Society for Cell Biology.The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a component
Modino, S, Cooley, C, Cooley, C., Farr, CJ, Farr, C. J., Slijepcevic, P., Baird, K. M., Stewart, J. L., Slijepcevic, P, Baird, KM, Wenner, T., Stewart, JL, Faure, V., Morrison, C. G., Morrison, CG, Wenner, T, Modino, S., Faure, V   +17 more
core   +1 more source

Biased genome editing using the local accumulation of DSB repair molecules system

Nature Communications, 2018
Genome editing using CRISPR can be enhanced by manipulating DNA double-strand break repair pathways. Here the authors demonstrate LoAD, local accumulation of repair molecules, which shifts repair to microhomology-mediated end-joining.
Shota Nakade, Keiji Mochida, Atsushi Kunii, Kazuki Nakamae, Tomomi Aida, Kohichi Tanaka, Naoaki Sakamoto, Tetsushi Sakuma, Takashi Yamamoto   +8 more
doaj   +1 more source