DNA double-strand break repair and development [PDF]
Oncogene, 2007 Normal development of an organism requires the ability to respond to DNA damage. A particularly deleterious lesion is a DNA double-strand break (DSB). The cellular response to DNA DSBs occurs via an integrated sensing and signaling network that maintains genomic stability.
E R, Phillips, P J, McKinnon
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Ataxia-telangiectasia Mutated (ATM)-dependent Activation of ATR Occurs through Phosphorylation of TopBP1 by ATM [PDF]
, 2007 ATM (ataxia-telangiectasia mutated) is necessary for activation of Chk1 by ATR (ATM and Rad3-related) in response to double-stranded DNA breaks (DSBs) but not to DNA replication stress. TopBP1 has been identified as a direct activator of ATR.
Dunphy, William G. +4 more
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Homologous pairing activities of two rice RAD51 proteins, RAD51A1 and RAD51A2. [PDF]
PLoS ONE, 2013 In higher eukaryotes, RAD51 functions as an essential protein in homologous recombination and recombinational repair of DNA double strand breaks. During these processes, RAD51 catalyzes homologous pairing between single-stranded DNA and double-stranded ...
Yuichi Morozumi +8 more
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A small RNA response at DNA ends in Drosophila [PDF]
, 2012 Small RNAs have been implicated in numerous cellular processes, including effects on chromatin structure and the repression of transposons. We describe the generation of a small RNA response at DNA ends in Drosophila that is analogous to the recently ...
Böttcher, Romy +2 more
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Physiological Roles of DNA Double-Strand Breaks [PDF]
Journal of Nucleic Acids, 2017 Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. Cells boast a considerable set of defences to both prevent and repair these breaks and drugs which derail these ...
Khan, Farhaan A, Ali, Syed O
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Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]
, 2008 Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi +34 more
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CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine [PDF]
, 2020 The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the
Ferreira, B I +2 more
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Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity
Molecular & Cellular Oncology, 2018 Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel
Elisa Gobbini +2 more
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G-quadruplex Structures Contribute to Differential Radiosensitivity of the Human Genome
iScience, 2019 Summary: DNA, the fundamental unit of human cell, generally exists in Watson-Crick base-paired B-DNA form. Often, DNA folds into non-B forms, such as four-stranded G-quadruplexes.
Nitu Kumari +7 more
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CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway
Protein & Cell, 2020 With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the most widely used gene editing technology in ...
Shuxiang Xu +6 more
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