Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones [PDF]
eLife, 2016 Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Martin Wilkinson +6 more
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Stationary-phase Pseudomonas aeruginosa fluoroquinolone persisters mostly avoid DNA double-stranded breaks [PDF]
mSphereWhen susceptible bacterial cultures are treated with antibiotics, some cells can survive treatment without heritable resistance, giving rise to susceptible daughter cells in a phenomenon termed antibiotic persistence.
Patricia J. Hare +2 more
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Theoretical, biological, and electrochemical explanation of the complexity of Peramivir’s drug–DNA interaction [PDF]
Scientific ReportsIn this study, an in-depth investigation was carried out on the interaction between the anti-influenza drug peramivir (PMV) and various DNA, including double-stranded DNA (dsDNA), single-stranded DNA (ssDNA), polyadenylic acid (PolyA), polyguanylic acid (
Monika Wypych +5 more
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Half a pack of cigarettes a day more than doubles DNA breaks in circulating leukocytes [PDF]
Tobacco Induced Diseases, 2010 Background The mechanisms by which smoking induces damage is not known for all diseases. One mechanism believed to play a role is oxidative stress. Oxidative stress leads to cellular damage including DNA damage, particularly DNA breaks. We conducted this
Maneli Mozaffarieh +4 more
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DNA double-strand break repair [PDF]
Current Biology, 1999 In yeast, the genes that encode Ku70 and Ku80 are essential to maintain the length of the telomeres — the specialized chromatin structures at the ends of chromosomes. Yeast Ku might act at the telomeres by protecting the DNA end from degradation and by clustering telomeres together at the nuclear periphery.
Featherstone, Carol, Jackson, Stephen P
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UPF1 promotes the formation of R loops to stimulate DNA double-strand break repair
Nature Communications, 2021 R loops are formed when single-stranded RNA anneals to one strand of DNA, forming three-stranded structures containing DNA-RNA hybrids and the displaced non-template single-stranded DNA. Here the authors reveal that the DNA:RNA helicase UPF1 plays a role
Greg H. P. Ngo +2 more
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Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks
Frontiers in Genetics, 2022 Loss or rearrangement of genetic information can result from incorrect responses to DNA double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly coordinated events designed to detect and respond appropriately to the damage,
Shaylee R. Kieffer, Noel F. Lowndes
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Function and Regulation of Nuclear DNA Sensors During Viral Infection and Tumorigenesis
Frontiers in Immunology, 2021 IFI16, hnRNPA2B1, and nuclear cGAS are nuclear-located DNA sensors that play important roles in initiating host antiviral immunity and modulating tumorigenesis.
Fan Zhang +6 more
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DNA Double-Strand Breaks [PDF]
The Journal of Experimental Medicine, 2002 The activation-induced cytidine deaminase (AID) is required for somatic hypermutation (SHM) and class-switch recombination (CSR) of immunoglobulin (Ig) genes, both of which are associated with DNA double-strand breaks (DSBs). As AID is capable of deaminating deoxy-cytidine (dC) to deoxy-uracil (dU), it might induce nicks (single strand DNA breaks) and ...
Linda Bross +4 more
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Splicing stimulates siRNA formation at Drosophila DNA double-strand breaks. [PDF]
PLoS Genetics, 2017 DNA double-strand breaks trigger the production of locus-derived siRNAs in fruit flies, human cells and plants. At least in flies, their biogenesis depends on active transcription running towards the break.
Karin Merk +6 more
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