Results 31 to 40 of about 61,553 (233)
Probing Meiotic Recombination Decisions [PDF]
Developmental Cell, 2008 Meiotic recombination promotes genetic variation by mixing parental alleles. Two recent studies, one in this issue of Developmental Cell, have applied microarray-based methods that allow analysis of nearly all of the recombination events occurring in a single meiosis.
Roig, Ignasi, Keeney, Scott
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PLoS Genetics, 2008 Heterozygous mutations in the tumor suppressor BRCA2 confer a high risk of breast and other cancers in humans. BRCA2 maintains genome stability in part through the regulation of Rad51-dependent homologous recombination. Much about its precise function in
Martha Klovstad +2 more
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Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination
Nature Communications, 2018 Homologous recombination ensures genome integrity during meiotic recombination. Here the authors reveal that factors SWS1 and SWSAP1 are critical for meiotic homologues recombination, particularly in promoting assembly of RAD51 and DMC1 on early ...
Carla M. Abreu +5 more
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The PHD finger protein Spp1 has distinct functions in the Set1 and the meiotic DSB formation complexes. [PDF]
PLoS Genetics, 2018 Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic recombination is initiated by programmed double-strand break (DSB) formation that in budding yeast takes place in gene ...
Céline Adam +10 more
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Cilia regulate meiotic recombination in zebrafish. [PDF]
J Mol Cell Biol, 2022 Abstract Meiosis is essential for evolution and genetic diversity in almost all sexual eukaryotic organisms. The mechanisms of meiotic recombination, such as synapsis, have been extensively investigated. However, it is still unclear whether signals from the cytoplasm or even outside of the cell can regulate the meiosis process.
Xie H +8 more
europepmc +4 more sources
Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2. [PDF]
, 2017 The HORMA domain is a highly conserved protein-protein interaction module found in eukaryotic signaling proteins including the spindle assembly checkpoint protein Mad2 and the meiotic HORMAD proteins.
Corbett, Kevin D +2 more
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Initiation of Meiotic Recombination in Mammals [PDF]
Genes, 2010 Meiotic recombination is initiated by the induction of programmed DNA double strand breaks (DSBs). DSB repair promotes homologous interactions and pairing and leads to the formation of crossovers (COs), which are required for the proper reductional segregation at the first meiotic division.
Kumar, Rajeev, de Massy, Bernard
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Genetics and Molecular Biology, 2003 The Escherichia coli RecA protein (RecAp) has been demonstrated to induce mutagenesis in yeast cells, although there is still little information on the role of the RecAp in yeast recombination events.
Marcos Antonio de Morais Junior +2 more
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Separation of DNA replication from the assembly of break-competent meiotic chromosomes. [PDF]
PLoS Genetics, 2012 The meiotic cell division reduces the chromosome number from diploid to haploid to form gametes for sexual reproduction. Although much progress has been made in understanding meiotic recombination and the two meiotic divisions, the processes leading up ...
Hannah G Blitzblau +3 more
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Cell Reports, 2020 Summary: Meiotic recombination is critical for genetic exchange and generation of chiasmata that ensures faithful chromosome segregation during meiosis I.
Kazumasa Takemoto +9 more
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