Results 51 to 60 of about 33,318 (207)

Alignment of Homologous Chromosomes and Effective Repair of Programmed DNA Double-Strand Breaks during Mouse Meiosis Require the Minichromosome Maintenance Domain Containing 2 (MCMDC2) Protein. [PDF]

PLoS Genetics, 2016
Orderly chromosome segregation during the first meiotic division requires meiotic recombination to form crossovers between homologous chromosomes (homologues).
Friederike Finsterbusch, Ramya Ravindranathan, Ihsan Dereli, Marcello Stanzione, Daniel Tränkner, Attila Tóth   +5 more
doaj   +1 more source

The Formation of Bivalents and the Control of Plant Meiotic Recombination

Frontiers in Plant Science, 2021
During the first meiotic division, the segregation of homologous chromosomes depends on the physical association of the recombined homologous DNA molecules.
Yared Gutiérrez Pinzón, José Kenyi González Kise, Patricia Rueda, Arnaud Ronceret   +3 more
doaj   +1 more source

Meiotic Recombination in Human Oocytes

PLoS Genetics, 2009
Studies of human trisomies indicate a remarkable relationship between abnormal meiotic recombination and subsequent nondisjunction at maternal meiosis I or II. Specifically, failure to recombine or recombination events located either too near to or too far from the centromere have been linked to the origin of human trisomies.
Cheng, Edith Y, Hunt, Patricia A, Naluai-Cecchini, Theresa A, Fligner, Corrine L, Fujimoto, Victor Y, Pasternack, Tanya L, Schwartz, Jackie M, Steinauer, Jody E, Woodruff, Tracey J, Cherry, Sheila M, Hansen, Terah A, Vallente, Rhea U, Broman, Karl W, Hassold, Terry J   +13 more
openaire   +5 more sources

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

SCF ensures meiotic chromosome segregation through a resolution of meiotic recombination intermediates.

PLoS ONE, 2012
The SCF (Skp1-Cul1-F-box) complex contributes to a variety of cellular events including meiotic cell cycle control, but its function during meiosis is not understood well.
Shin-ya Okamoto, Masamitsu Sato, Takashi Toda, Masayuki Yamamoto   +3 more
doaj   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

Mek1 coordinates meiotic progression with DNA break repair by directly phosphorylating and inhibiting the yeast pachytene exit regulator Ndt80.

PLoS Genetics, 2018
Meiotic recombination plays a critical role in sexual reproduction by creating crossovers between homologous chromosomes. These crossovers, along with sister chromatid cohesion, connect homologs to enable proper segregation at Meiosis I. Recombination is
Xiangyu Chen, Robert Gaglione, Trevor Leong, Lauren Bednor, Teresa de Los Santos, Ed Luk, Michael Airola, Nancy M Hollingsworth   +7 more
doaj   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis.

PLoS ONE, 2007
Meiosis is a defining feature of eukaryotes but its phylogenetic distribution has not been broadly determined, especially among eukaryotic microorganisms (i.e. protists)-which represent the majority of eukaryotic 'supergroups'.
Shehre-Banoo Malik, Arthur W Pightling, Lauren M Stefaniak, Andrew M Schurko, John M Logsdon   +4 more
doaj   +1 more source

ReCombine: a suite of programs for detection and analysis of meiotic recombination in whole-genome datasets. [PDF]

PLoS ONE, 2011
In meiosis, the exchange of DNA between chromosomes by homologous recombination is a critical step that ensures proper chromosome segregation and increases genetic diversity.
Carol M Anderson, Stacy Y Chen, Michelle T Dimon, Ashwini Oke, Joseph L DeRisi, Jennifer C Fung   +5 more
doaj   +1 more source