ABSTRACT Objective Autosomal dominant progranulin (GRN) pathogenic variants are a genetic cause of frontotemporal lobar degeneration. Though clinical trials for GRN‐related therapies are underway, there is an unmet need for biomarkers that can predict symptom onset and track disease progression.
Taru M. Flagan +46 more
wiley +1 more source
Sliding mode dynamics of a non-smooth Filippov predator-prey system for integrated pest management. [PDF]
Liu J, Hu J, Song H.
europepmc +1 more source
ABSTRACT Objective Cognitive impairment (CI) affects the quality of life in multiple sclerosis (MS). Identifying influencing factors is key to improving CI monitoring. This systematic review and meta‐analysis examines clinical and sociodemographic variables impacting the cognitive screening Symbol Digit Modalities Test (SDMT) performance across MS ...
Katalin Lugosi +8 more
wiley +1 more source
Three-dimensional motion analysis of the trailing limb in obstacle crossing during gait in young adults: foot trajectory changes with the height of obstacles. [PDF]
Kasuga T +3 more
europepmc +1 more source
Tait's conjectures and odd crossing number amphicheiral knots
A. Stoimenow
openalex +2 more sources
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Nanobody conjugated with dendrimer nanoparticles effectively neutralizes tick-borne encephalitis virus. [PDF]
Jozefiaková J +8 more
europepmc +1 more source
Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski +13 more
wiley +1 more source
A pedestrian group crossing intention prediction model integrating spatiotemporal features. [PDF]
Zou H +5 more
europepmc +1 more source
Approximating Spanning Trees with Low Crossing Number
Sariel Har-Peled
openalex +2 more sources

