Results 151 to 160 of about 624,423 (312)

Is protein folding problem really a NP-complete one ? First investigations

, 2013
To determine the 3D conformation of proteins is a necessity to understand their functions or interactions with other molecules. It is commonly admitted that, when proteins fold from their primary linear structures to their final 3D conformations, they ...
Bahi, Jacques M., Bienia, Wojciech, Côté, Nathalie, Guyeux, Christophe   +3 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Screening natural oil palm (Elaeis guineensis Jacq.) populations using SSR markers [PDF]

, 2009
The assessment of genetic diversity and genetic structure of natural oil palm populations is carried out mostly for crop improvement purpose. A set of 16 microsatellite markers was used to genotype 494 palms from 49 populations belonging to ten African ...
Bakoumé, Claude, Billotte, Norbert, Kushairi, Ahmad, Rajanaidu, Nookiah, Wickneswari, Ratnam   +4 more
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ESTIMATION OF GENETIC EFFECTS ON PLANT HEIGHT IN TWO SPECIFIC PAIRS OF INBRED LINES AND ITS SIX BASIC GENERATIONS [PDF]

Poljoprivreda, 2003
Estimation of genetic effects on economically important traits is a common procedure in the most breeding programmes at Agricultural Institute Osijek. This paper deals with estimation of adequacy over additive/dominance model of inheritance as well as ...
Zvonimir Zdunić, Domagoj Šimić, Ivan Brkić, Antun Jambrović, Renata Zdunić, Tatjana Ledenčan   +5 more
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Genetic Gain and Inbreeding in Different Simulated Genomic Selection Schemes for Grain Yield and Oil Content in Safflower

Plants
Safflower (Carthamus tinctorius L.) is a multipurpose minor crop consumed by developed and developing nations around the world with limited research funding and genetic resources.
Huanhuan Zhao, Majid Khansefid, Zibei Lin, Matthew J. Hayden   +3 more
doaj   +1 more source

A simple two-module problem to exemplify building-block assembly under crossover

, 2004
Theoretically and empirically it is clear that a genetic algorithm with crossover will outperform a genetic algorithm without crossover in some fitness landscapes, and vice versa in other landscapes.
D. Wolpert, D.E. Goldberg, G. Syswerda, H. Muhlenbein, J.C. Culberson, J.H. Holland, J.H. Holland, K. Deb, M. Mitchell, M. Mitchell, P. Gitchoff, P.F. Stadler, R.A. Fisher, R.A. Watson, R.A. Watson, S. Forrest, S. Forrest, S. Wright   +17 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source