Results 161 to 170 of about 624,423 (312)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Cis‐ and trans‐acting genetic factors contribute to heterogeneity in the rate of crossing over between the Drosophila simulans clade species

Journal of Evolutionary Biology, 2012
M. Cattani, S. Kingan, Daven C. Presgraves   +2 more
semanticscholar   +1 more source

Animal breeding in organic farming:Discussion paper [PDF]

, 2001
It is uncertain whether animals which have been bred for conventional production are capable of optimum performance in organic conditions. In conventional agriculture there is a movement towards maximum control of production conditions in order to ...
Baars, Nauta, Groen, Ab, Nauta, Wytze, Roep, Dirk, Veerkamp, Roel   +4 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Plant breeding for organic farming: current status and problems in Europe [PDF]

, 2005
Compendium is a part of Deliverable 4 of 6th FP SSA project “Environmental friendly food production system: requirements for plant breeding and seed production” (ENVIRFOOD) and contains information about current status and problems in EU regarding to ...
Legzdina, Linda, Skrabule, Ilze
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

CONTROLUL GENETIC AL MEIOZEI LA PLANTE

Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2013
Meioza este un proces biologic fundamental al eucariotelor cu reproducere sexuată. În această lucrare vom revizui progresele realizate în ultimii ani pentru izolarea genelor meiotice la diferite specii de plante.
USM ADMIN
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Hexaploid-bridged introgression broadens genetic diversity and enriches clubroot-resistance alleles in Brassica juncea

Frontiers in Plant Science
IntroductionThe narrow genetic base of current Brassica juncea (AABB) has limited the genetic improvement of this crop.MethodsIn this study, we developed novel germplasm by crossing synthetic hexaploid bridge lines (AABBBB and AAAABB) with diploid ...
Yongzhi Wu, Yongzhi Wu, Yongzhi Wu, Jingyan Liao, Jingyan Liao, Jingyan Liao, Yinquan Deng, Yinquan Deng, Yinquan Deng, Fuquan Ce, Fuquan Ce, Fuquan Ce, Peng Bai, Lisha Peng, Lisha Peng, Xingxing Zhang, Xingxing Zhang, Yi Wan, Wei Qian, Wei Qian, Wei Qian, Jiaqin Mei, Jiaqin Mei, Jiaqin Mei   +23 more
doaj   +1 more source