Results 71 to 80 of about 1,320,415 (233)

Crossing Over: Sustainability, New Urbanism, and Gentrification in Austin, Texas

open access: yesSouthern Spaces, 2015
In this essay, Andrew M. Busch discusses the histories of segregation and gentrification in Austin, Texas's Eastside and examines the rise of New Urbanism in the development of the Eastside's Eleventh Street corridor.
Andrew M. Busch
doaj   +1 more source

Knot Probabilities in Random Diagrams

open access: yes, 2015
We consider a natural model of random knotting- choose a knot diagram at random from the finite set of diagrams with n crossings. We tabulate diagrams with 10 and fewer crossings and classify the diagrams by knot type, allowing us to compute exact ...
Cantarella, Jason   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Highways, crossing structures and risk: Behaviors of Greater Yellowstone pronghorn elucidate efficacy of road mitigation

open access: yesGlobal Ecology and Conservation, 2018
Wildlife crossing structures and accompanying barrier fencing can prevent large mammals from accessing road surfaces and can significantly reduce wildlife-vehicle collisions while allowing animals to move from one side of the road to the other.
Renee G. Seidler   +2 more
doaj   +1 more source

Metastable Evolutionary Dynamics: Crossing Fitness Barriers or Escaping via Neutral Paths?

open access: yes, 1999
We analytically study the dynamics of evolving populations that exhibit metastability on the level of phenotype or fitness. In constant selective environments, such metastable behavior is caused by two qualitatively different mechanisms. One the one hand,
Crutchfield, James P.   +1 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Farming across the years: temporal and spatial dimensions of learning organic farming [PDF]

open access: yes, 2002
In organic farming, it is generally accepted that a long-term perspective spanning across the years is necessary for the sustainability of organic field management. This paper analyzes the crossing over of annual boundaries during an organic inspection
Koskimies, H., Seppänen, L.
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Weighted Euler characteristic of the moduli space of higher rank Joyce-Song pairs

open access: yes, 2016
The invariants of rank 2 Joyce-Song semistable pairs over a Calabi-Yau threefold were computed in arXiv:1101.2252, using the wall-crossing formula of Joyce-Song and Kontsevich-Soibelman.
Sheshmani, Artan
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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