Results 141 to 150 of about 68,815 (309)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Identifying MESSENGER Magnetospheric Boundary Crossings Using a Random Forest Region Classifier

Journal of Geophysical Research: Machine Learning and Computation
We present a new list of bow shock and magnetopause crossings based on automated region classification for the MESSENGER (Mercury Surface, Space Environment, Geochemistry and Ranging) mission.
Daragh M. Hollman, Caitríona M. Jackman, Katarina Domijan, Charles F. Bowers, Simon J. Walker, Matthew J. Rutala, Alexandra R. Fogg   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Translating Violence: Exploring the Relationship between Regional Masculinity, the Combatant Male and the Perpetration of Sexual Crimes during times of Conflict

This paper examines the relationship between regional concepts of manhood and the experience of wartime sexual violence for the sub-group that is highly at risk of its victimization and its perpetration, the combatant-male.
Perez, Christian
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Study of the Durability of Materials Used in Turnout Crossings

Studies of the durability of heavily loaded crossings in Latvian Railway provide information about the use of innovative materials and the impact of geometric improvements on their design. An empiric connection has been found on the basis of experimental
Brutāns, Valdis, Torims, Toms
core  

Amnesty International’s “Stolen Sisters” Report: Martyrdom and Unintended Challenges of Life Narratives

This paper examines the efficacy and ethical implications of using life narratives in representing the Missing and Murdered Indigenous Women and Girls crisis  (MMIWG) in Canada, focusing specifically on Amnesty International\u27s 2004 "Stolen ...
Naidoo, Sithara
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Method for a structured identification of suitable safety and securing systems for Level Crossings

, 2009
Safety and securing systems for level crossing have a long life time. Once a system reaches a life time when it is no longer conform to applicable regulations, it has to be modernized or replaced.
Pelz, Markus, Asbrock, Hartwig, Böhm, Thomas   +2 more
core