Results 31 to 40 of about 38,232 (245)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
RNA Crosslinking Methods [PDF]
, 2009 RNA-RNA crosslinking provides a rapid means of obtaining evidence for the proximity of functional groups in structurally complex RNAs and ribonucleoproteins. Such evidence can be used to provide a physical context for interpreting structural information from other biochemical and biophysical methods and for the design of further experiments.
Michael E, Harris, Eric L, Christian
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Innovative Water-Insoluble Edible Film Based on Biocatalytic Crosslink of Gelatin Rich in Glutamine
Foods, 2020 Gelatin is a promising candidate for making bioplastic film; however, the water soluble property has limited its applications. Here, we have successfully fabricated a water-insoluble gelatin film with the assistance of biocatalysis.
Yanli Ma, Ruijin Yang, Wei Zhao
doaj +1 more source
Ultraviolet Corneal Crosslinking
Annals of the Russian academy of medical sciences, 2016 This review presents basic information on UV corneal crosslinking. The method is widely used in ophthalmology to treat various types of ectasia, which are characterized by progressive degenerative changes in the cornea, associated with its thinning , hazing and scarring, which leads to a significant reduction in visual acuity.
M M, Bikbov, A R, Khalimov, E L, Usubov
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Devulcanization of Natural Rubber in Composites with Distinct Crosslink Densities by Twin-Screw Extruder [PDF]
Materials Research, 2017 In this study, the effects of the devulcanization process realized by an intermeshing co-rotating twin-screw extruder (ICTSE) on three vulcanized Natural Rubber (NR) composites with different crosslink densities (CD) have been investigated. The extrusion
Rafael Barbosa +2 more
doaj +1 more source
陆军军医大学学报, 2023 Objective To investigate the effect of DNA damage protein targeting VCP (DVC1) in DNA protein crosslink repair induced by nitrogen mustard in human bronchial epithelial cells (16HBE). Methods DVC1 siRNA was used to interfere its expression in 16HBE. Then
CHENG Jin, YU Wenpei, YE Feng
doaj +1 more source
Chemistry – A European Journal, 2017 AbstractCrosslinking is an essential architecture for polymers to improve mechanical and thermal properties and to form three‐dimensional (3D) structures. Although conventional synthetic crosslinkers usually only serve as bridges between different polymeric chains, biological crosslinkers are multifunctional.
Ning Zhou, Zeyuan Cao, Bing Xu
openaire +3 more sources
Sustainable bioplastics manufacturing from renewable sources
FEBS Open Bio, EarlyView.Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto +6 more
wiley +1 more source