Results 41 to 50 of about 38,232 (245)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Synthesis of Peptide Nucleic Acids Containing a Crosslinking Agent and Evaluation of Their Reactivities

Molecules, 2015
Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA.
Takuya Akisawa, Yuki Ishizawa, Fumi Nagatsugi   +2 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Food Simulating Organic Solvents for Evaluating Crosslink Density of Bulk Fill Composite Resin

International Journal of Dentistry, 2017
Objectives. To evaluate crosslink densities of two bulk fill composite resins and determine if the used Food Simulating Organic Solvent (FSOS) affected them. Methods.
Neveen M. Ayad, Hala A. Bahgat, Eman Hussain Al Kaba, Maryam Hussain Buholayka   +3 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

The Contact Simulation Comparison of UHMWPE to the Crosslink Intensity Effect

E3S Web of Conferences, 2018
Ultra High Molecular Weight Polyethylene called UHMWPE is a unique polymer material that has excellent physical and mechanical properties. UHMWPE material is frequently used in prosthesis.
Al Hakim Reza Azizul Nasa, Arrohman Sigit, Saputra Eko, Anwar Iwan Budi, Jamari J, Ismail Rifky, Bayuseno Athanasius P., Tauviqirrahman Mohammad   +7 more
doaj   +1 more source

Enhancement of the Controlled-Release Properties of Chitosan Membranes by Crosslinking with Suberoyl Chloride

Molecules, 2013
A novel crosslinking agent, suberoyl chloride, was used to crosslink N-phthaloyl acylated chitosan and improves the properties of chitosan membranes. Membranes with different crosslinking degrees were synthesized.
Xiaoyun Qiu, Shuwen Hu, Zideng Gao, Chao Chen   +3 more
doaj   +1 more source

Influence of Network Topology on the Viscoelastic Properties of Dynamically Crosslinked Hydrogels

Frontiers in Chemistry, 2020
Biological materials combine stress relaxation and self-healing with non-linear stress-strain responses. These characteristic features are a direct result of hierarchical self-assembly, which often results in fiber-like architectures.
Emilia M. Grad, Emilia M. Grad, Isabell Tunn, Dion Voerman, Dion Voerman, Alberto S. de Léon, Roel Hammink, Roel Hammink, Kerstin G. Blank, Kerstin G. Blank   +9 more
doaj   +1 more source

Is Young's Modulus a Critical Coating Property Determining Fouling‐Release Performance of Marine Coatings?

Advanced Engineering Materials, EarlyView.
The release of foulers from protective marine coatings is determined by several interrelated material properties, including the strength of Young's modulus, the flexibility of chain segments, the surface free energy, and the magnitude of hydrodynamic stress.
Johann C. Schaal, Andreas Brinkmann, Andreas Hartwig   +2 more
wiley   +1 more source

Stress relaxation through crosslink unbinding in cytoskeletal networks

New Journal of Physics, 2012
The mechanical properties of cells are dominated by the cytoskeleton, an interconnected network of long elastic filaments. The connections between the filaments are provided by crosslinking proteins, which constitute, next to the filaments, the second ...
C Heussinger
doaj   +1 more source