Results 51 to 60 of about 185,186 (338)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The biomechanical fundamentals of crosslink-augmentation in posterior spinal instrumentation
Scientific Reports, 2022 Posterior screw-rod constructs can be used to stabilize spinal segments; however, the stiffness is not absolute, and some motion can persist. While the effect of crosslink-augmentation has been evaluated in multiple studies, the fundamental explanation ...
Frédéric Cornaz +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Applied Sciences, 2020 Selective chemical reactions of biomolecules are some of the important tools for investigations by biological studies. We have developed the selective crosslinking reactions to form covalent bonds to DNA or RNA using crosslinking oligonucleotides (CFO ...
Kenta Odaira +4 more
doaj +1 more source
Polyelectrolyte Networks: Elasticity, Swelling, and the Violation of the Flory - Rehner Hypothesis
, 1997 This paper discusses the elastic behavior of polyelectrolyte networks. The deformation behavior of single polyelectrolyte chains is discussed. It is shown that a strong coupling between interactions and chain elasticity exists. The theory of the complete
Vilgis, T. A., Wilder, J.
core +1 more source
Size and scaling in ideal polymer networks [PDF]
, 1996 The scattering function and radius of gyration of an ideal polymer network are calculated depending on the strength of the bonds that form the crosslinks.
Solf, M. P., Vilgis, T. A.
core +2 more sources
RNA Crosslinking Methods [PDF]
, 2009 RNA-RNA crosslinking provides a rapid means of obtaining evidence for the proximity of functional groups in structurally complex RNAs and ribonucleoproteins. Such evidence can be used to provide a physical context for interpreting structural information from other biochemical and biophysical methods and for the design of further experiments.
Michael E, Harris, Eric L, Christian
openaire +2 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Langevin Dynamics of a Polymer with Internal Distance Constraints
, 1996 We present a novel and rigorous approach to the Langevin dynamics of ideal polymer chains subject to internal distance constraints. The permanent constraints are modelled by harmonic potentials in the limit when the strength of the potential approaches ...
Solf, M. P., Vilgis, T. A.
core +1 more source
Ultraviolet Corneal Crosslinking
Annals of the Russian academy of medical sciences, 2016 This review presents basic information on UV corneal crosslinking. The method is widely used in ophthalmology to treat various types of ectasia, which are characterized by progressive degenerative changes in the cornea, associated with its thinning , hazing and scarring, which leads to a significant reduction in visual acuity.
M M, Bikbov, A R, Khalimov, E L, Usubov
openaire +3 more sources