Results 21 to 30 of about 218,047 (260)

The Multifaceted Roles of MYC2 in Plants: Toward Transcriptional Reprogramming and Stress Tolerance by Jasmonate Signaling

Frontiers in Plant Science, 2022
Environmental stress is one of the major restrictions on plant development and foodstuff production. The adaptive response in plants largely occurs through an intricate signaling system, which is crucial for regulating the stress-responsive genes ...
Cheng Song, Yunpeng Cao, Jun Dai, Guohui Li, Muhammad Aamir Manzoor, Cunwu Chen, Hui Deng   +6 more
doaj   +1 more source

Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer

Frontiers in Oncology, 2014
The Notch pathway is a well-established mediator of cell-cell communication that plays a critical role in stem cell survival, self-renewal, cell fate decisions, tumorigenesis, invasion, metastasis, and drug resistance in a variety of cancers.
Andrew T Baker, Andrei eZlobin, Clodia eOsipo   +2 more
doaj   +1 more source

A step-by-step guide to performing cancer metabolism research using custom-made media

Life Science Alliance
We present a detailed step-by-step protocol for preparing custom-made cell culture media and provide guidance on its use in cancer metabolism experiments.
Sophie Seifert, Francisco Yanqui-Rivera, Tim Kühn, Lena Elise Høyland, Toman Borteçen, Bella Agranovich, Lara Elea Eckhardt, Martin Herdt, Alessa Henneberg, Verena Panitz, Faisal Hayat, Marie Migaud, Gernot Poschet, Ifat Abramovich, Eyal Gottlieb, Jeroen Krijgsveld, Mathias Ziegler, Mirja Tamara Prentzell, Christiane A Opitz   +18 more
doaj   +1 more source

Crosstalk

, 2023
Crosstalk es un álbum de Harsh Noise, compuesto íntegramente por ciclos infinitos de retroalimentación estridentes, envueltos en infinitas capas de resonancias metálicas y aspereza electrónica. Ha sido generado completamente mediante la utilización de Inteligencia Artificial, abarcando desde su aspecto visual hasta su contenido sonoro.
Andrew Peterson, Gregory Durgin
openaire   +4 more sources

Tissue-Specific Impact of Autophagy Genes on the Ubiquitin–Proteasome System in C. elegans

Cells, 2020
The ubiquitin–proteasome system (UPS) and the autophagy–lysosomal pathway (ALP) are the two main eukaryotic intracellular proteolytic systems involved in maintaining proteostasis.
Sweta Jha, Carina I. Holmberg
doaj   +1 more source

T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer

OncoImmunology, 2021
The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor micro-environment (TME).
Richard A O’Connor, Vishwani Chauhan, Layla Mathieson, Helen Titmarsh, Lilian Koppensteiner, Irene Young, Giulia Tagliavini, David A Dorward, Sandrine Prost, Kevin Dhaliwal, William A Wallace, Ahsan R Akram   +11 more
doaj   +1 more source

Hydrogen Sulfide: From a Toxic Molecule to a Key Molecule of Cell Life

Antioxidants, 2020
Hydrogen sulfide (H2S) has always been considered toxic, but a huge number of articles published more recently showed the beneficial biochemical properties of its endogenous production throughout all regna.
Angeles Aroca, Cecilia Gotor, Diane C. Bassham, Luis C. Romero   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source