Results 31 to 40 of about 294,375 (288)
Tissue-Specific Impact of Autophagy Genes on the Ubiquitin–Proteasome System in C. elegans
Cells, 2020 The ubiquitin–proteasome system (UPS) and the autophagy–lysosomal pathway (ALP) are the two main eukaryotic intracellular proteolytic systems involved in maintaining proteostasis.
Sweta Jha, Carina I. Holmberg
doaj +1 more source
OncoImmunology, 2021 The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor micro-environment (TME).
Richard A O’Connor +11 more
doaj +1 more source
Repeater insertion to minimise delay in coupled interconnects. [PDF]
, 2001 Signalling over long interconnect is a dominant issue in electronic chip design in current technologies, with the device sizes getting smaller and smaller and the circuits becoming ever larger.
Tenhunen, Hannu, Pamunuwa, Dinesh B.
core +5 more sources
Hydrogen Sulfide: From a Toxic Molecule to a Key Molecule of Cell Life
Antioxidants, 2020 Hydrogen sulfide (H2S) has always been considered toxic, but a huge number of articles published more recently showed the beneficial biochemical properties of its endogenous production throughout all regna.
Angeles Aroca +3 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Modelling and analysis of crosstalk in scaled CMOS interconnects [PDF]
, 1995 The development of a general coupled RLC interconnect model for simulating scaled bus structures m VLSI is presented. Several different methods for extracting submicron resistance, inductance and capacitance parameters are documented.
Mahoney, Patrick Francis
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A Computationally Efficient Hybrid Framework for Polarimetric Calibration of Quad‐Pol SAR Data
Earth and Space Science, 2021 Polarimetric Synthetic Aperture Radar (PolSAR) calibration is an essential preprocessing step that must be performed to ensure that the data quality is adequate. This, in turn, helps to minimize the propagation of errors in any further data processing or
Abhisek Maiti +3 more
doaj +1 more source