Results 31 to 40 of about 1,362 (185)

Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a ...
Leonardo A. Calderon, Juliana C. Sobrinho, Kayena D. Zaqueo, Andrea A. de Moura, Amy N. Grabner, Maurício V. Mazzi, Silvana Marcussi, Auro Nomizo, Carla F. C. Fernandes, Juliana P. Zuliani, Bruna M. A. Carvalho, Saulo L. da Silva, Rodrigo G. Stábeli, Andreimar M. Soares, Fernando Albericio   +14 more
wiley   +1 more source

Antiophidian properties of plant extracts against Lachesis muta venom [PDF]

, 2010
Snakebites comprise a serious health problem in several countries due to their global incidence, which exceeds 2.5 million per year, and the elevated number of victim fatalities.
COSTA, TR, DE PAULA, RC, FULY, AL, LOURENÇO, MV, MARTINS, CHG, PEREIRA, PS, SANCHEZ, EF, SOARES, AM   +7 more
core   +2 more sources

Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae)

International Scholarly Research Notices, Volume 2014, Issue 1, 2014., 2014
Eclipta alba can be found growing wild in fallow lands of Bangladesh where it is considered as a weed by farmers. Traditional medicinal systems of the Indian subcontinent countries as well as tribal practitioners consider the plant to have diverse medicinal values and use it commonly for treatment of gastrointestinal disorders, respiratory tract ...
Rownak Jahan, Abdullah Al-Nahain, Snehali Majumder, Mohammed Rahmatullah, Jagadananda Ghosh   +4 more
wiley   +1 more source

Biochemical, Pharmacological, and Structural Characterization of New Basic PLA2 Bbil‐TX from Bothriopsis bilineata Snake Venom

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
Bbil‐TX, a PLA2, was purified from Bothriopsis bilineata snake venom after only one chromatographic step using RP‐HPLC on μ‐Bondapak C‐18 column. A molecular mass of 14243.8 Da was confirmed by Q‐Tof Ultima API ESI/MS (TOF MS mode) mass spectrometry. The partial protein sequence obtained was then submitted to BLASTp, with the search restricted to PLA2 ...
Victor Corasolla Carregari, Rafael Stuani Floriano, Lea Rodrigues-Simioni, Flavia V. Winck, Paulo Aparecido Baldasso, Luis Alberto Ponce-Soto, Sergio Marangoni, Laura Leiva   +7 more
wiley   +1 more source

Snake Venom: Any Clue for Antibiotics and CAM?

Evidence-Based Complementary and Alternative Medicine, Volume 2, Issue 1, Page 39-47, 2005., 2005
Lately several naturally occurring peptides presenting antimicrobial activity have been described in the literature. However, snake venoms, which are an enormous source of peptides, have not been fully explored for searching such molecules. The aim of this work is to review the basis of antimicrobial mechanisms revealing snake venom as a feasible ...
Deivy Clementino de Lima, Paula Alvarez Abreu, Cícero Carlos de Freitas, Dilvani Oliveira Santos, Rodrigo Oliveira Borges, Tereza Cristina dos Santos, Lúcio Mendes Cabral, Carlos R. Rodrigues, Helena Carla Castro   +8 more
wiley   +1 more source

Bacterial Adaptation to Venom in Snakes and Arachnida [PDF]

, 2022
Animal venoms are considered sterile sources of antimicrobial compounds with strong membrane-disrupting activity against multidrug-resistant bacteria. However, venomous bite wound infections are common in developing nations.
Barlow, Axel, Barlow, Axel, Dalby, Andrew, Dalby, Andrew, Davies, Sam, Davies, Sam, Denise, Hubert, Denise, Hubert, Esmaeilishirazifard, Elham, Esmaeilishirazifard, Elham, Kremyda-Vlachou, Myrto, Kremyda-Vlachou, Myrto, Lock, Mikaella M G, Lock, Mikaella M G, Loftus, Teresa D, Loftus, Teresa D, Moschos, S., Moschos, S., Redway, Keith F, Redway, Keith F, Sangal, V., Sangal, V., Snyder, L., Snyder, L., Taylor, John D, Taylor, John D, Trim, Carol, Trim, Carol, Trim, Steve, Trim, Steve, Tyson, G., Tyson, G., Usher, Louise, Usher, Louise, Wright, Kstir, Wright, Kstir, Wuster, Wolfgang, Wuster, Wolfgang   +37 more
core   +1 more source

Assay of phospholipases A2 and their inhibitors by kinetic analysis in the scooting mode

Mediators of Inflammation, Volume 1, Issue 2, Page 85-100, 1992., 1992
Several cellular processes are regulated by interfacial catalysis on biomembrane surfaces. Phospholipases A2 (PLA2) are interesting not only as prototypes for interfacial catalysis, but also because they mobilize precursors for the biosynthesis of eicosanoids and platelet activating factor, and these agents ultimately control a wide range of secretory ...
Mahendra Kumar Jain, Bao-Zhu Yu, Michael H. Gelb, Otto G. Berg   +3 more
wiley   +1 more source

Epidemiology and characteristics of coral snake bites reported to the National Poison Data System (2006‒2022)

Journal of the American College of Emergency Physicians Open, Volume 5, Issue 5, October 2024.
Abstract Objectives North American coral snake envenomations can result in life‐threatening neurotoxicity. Their bites are relatively rare, making large studies difficult. Using the National Poison Data System (NPDS), we sought to investigate the epidemiological trends and clinical outcomes associated with North American coral snake bites over a 17 ...
Mary E. Velagapudi, Juliana J. Navarro, Alexander E. Hill, Michael A. Darracq, Stephen L. Thornton   +4 more
wiley   +1 more source

The effects of hyperbaric oxygen therapy on snake‐bite‐associated wounds in dogs

Journal of Veterinary Emergency and Critical Care, Volume 34, Issue 3, Page 211-221, May/June 2024.
Abstract Objective To assess the effect of hyperbaric oxygen therapy (HBOT) on Crotalinae envenomation‐induced wound swelling and severity and pain in dogs, and to describe the safety and complications of HBOT. Design Prospective, randomized, controlled, blinded study (2017–2021).
Shelly Olin, Julie Schildt, Michael Lane, Adesola Odunayo, Cary Springer, Dana Call, Selene Jones, Dennis Geiser, Daryl Millis, Marti Drum   +9 more
wiley   +1 more source

Interactions of small molecule inhibitors with secreted phospholipase A2: A review of the structural data

Chemical Biology &Drug Design, Volume 103, Issue 2, February 2024.
Due to their roles in inflammation, the sPLA2 enzymes are of much medicinal interest. sPLA2 inhibitors have been developed for the treatment of inflammatory and other conditions such as cardiovascular disease, arteriosclerosis and rheumatoid arthritis.
Chantalle Crous, Anél Petzer, Jacobus P. Petzer   +2 more
wiley   +1 more source