Results 31 to 40 of about 5,737 (266)

Theoretical Determination of Subsonic Oscillatory Airforce Coefficients for Cruciform-Tail Configurations

open access: yesJournal of Algorithms & Computational Technology, 2007
This paper presents the theoretical development of lifting surface theory for the calculation of aerodynamic airforce coefficients for cruciform-tail configurations. The cruciform tail is assumed to vibrate in simple harmonic motion in a subsonic airflow
C.W. Cheung
doaj   +1 more source

DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation

open access: yesMolecular Cytogenetics, 2011
Background Cumulative evidence suggests that DNA secondary structures impact DNA replication, transcription and genomic rearrangements. One of the best studied examples is the recurrent constitutional t(11;22) in humans that is mediated by potentially ...
Tsutsumi Makiko   +8 more
doaj   +1 more source

Insights into Cruciform Sample Design [PDF]

open access: yesJOM, 2017
Four different cruciform sample designs, based on the work of Abu-Farha et al., were studied in this paper. Key features of this design are a recessed pocket with fillet and re-entrant corners. These samples were shown via digital image correlation to achieve widely differing strain values inside and outside the pocket. From the results of these tests,
A, Creuziger   +4 more
openaire   +2 more sources

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

open access: yesAdvanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang   +6 more
wiley   +1 more source

Steel Cruciform Sample with Nitrided Arms Achieves Higher Plastic Strain in the Gauge Region

open access: yesApplied Sciences, 2022
This paper describes a novel solution to increase plastic strain in the gauge region of a cruciform sample during a forming limit test. A nitriding procedure was used to increase the strength of the arms of the specimen and at the same time enabled ...
Grzegorz Mitukiewicz
doaj   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

open access: yesAdvanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang   +8 more
wiley   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

open access: yesAdvanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai   +11 more
wiley   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

open access: yesAdvanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma   +10 more
wiley   +1 more source

Topical glucocorticoids and the skin-mechanisms of action: an update

open access: yesMediators of Inflammation, 1998
The topical glucocorticoids (GCs) represent the treatment of choice for many types of inflammatory dermatoses. Despite the extensive use of this class of drugs as first line therapy the mechanism of their action is uncertain.
A. Ahluwalia
doaj   +1 more source

Creep Damage Evaluation using Uniaxial Miniature Specimens for Multiaxially Damaged Components [PDF]

open access: yesMATEC Web of Conferences, 2019
This study discusses a method of evaluating multiaxial creep damage for high temperature components subjected to multiaxial creep damage utilizing a miniature creep testing.
Kosaka Rui   +3 more
doaj   +1 more source

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