Results 61 to 70 of about 40,289 (297)
Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy
Advanced Science, EarlyView.Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan +14 more
wiley +1 more source
Los dos Saverios: delirio, poder y espectáculo en Roberto Arlt
Iberoamericana. América Latina - España - Portugal, 2014 Este ensayo examina la noción de teatralidad –especialmente en su variante experimental o vanguardista– en la escritura de Roberto Arlt, tomando como eje la primera versión de Saverio el cruel, obra inédita y no leída críticamente hasta la fecha a pesar ...
Julio Prieto
doaj +1 more source
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source
Advanced Science, EarlyView.A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang +12 more
wiley +1 more source
, 1972 cruel a..."Cruel" used to mean something large, such as "a cruel pair of feet".JH 3/72Used I and SupUsed I and Sup2Not UsedSOME, WONDERFULChecked by Jordyn Hughes on Wed 29 Jun ...
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AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
Advanced Science, EarlyView.A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li +8 more
wiley +1 more source
, 1973 cruel a[PT] "Cruel" usually means quantity,and I remember on one occasion a girl guide commissioner visited a village where I was working at the time.She had a great many medals and so on,and it was said of her that she had "a cruel mess of gear on
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Cruel and unusual: Sentencing 13- and 14-year-old children to die in prison
, 2008 In the United States, dozens of 13- and 14-year-old children have been sentenced to life imprisonment with no possibility of parole after being prosecuted as adults. While the United States Supreme Court recently declared in Roper v.
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Advanced Science, EarlyView.A ZIF‐90 nanocarrier delivers dinotefuran and suppresses NlABCG3 and NlABCH1 in resistant Nilaparvata lugens. This system combines pH/ATP‐triggered release with enhanced foliar retention, improving efficacy while sparing honeybees and promoting rice growth, offering a promising resistance‐breaking strategy.
Chengshuai He +9 more
wiley +1 more source