Results 51 to 60 of about 22,997 (266)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu   +13 more
wiley   +1 more source

Numerical analysis of bubble coalescence characteristics on wetting surface

open access: yesZhongguo Jianchuan Yanjiu
ObjectiveThis study aims to advance the development of composite drag reduction technology involving super-hydrophobic surfaces and bubbles by investigating the coalescence characteristics of bubbles on wetting surfaces and revealing the effects of ...
Liuming YANG   +3 more
doaj   +1 more source

Navigating the Campus [PDF]

open access: yesSocial Sciences and Education Research Review
The research in this paper reviews the literature on students with disabilities (SWDs) in higher education to assess their access to education. show the need for every instructor and educational institution to ensure that students' needs are meet ...
Easaw Alemayehu ASSEFA   +1 more
doaj   +1 more source

Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan

open access: yesEmerging Infectious Diseases, 2020
An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages ...
Takuya Adachi   +15 more
doaj   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

open access: yesAdvanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv   +16 more
wiley   +1 more source

Large-Eddy Simulation of Low-Frequency Flow Oscillations for NACA0012 and Dynarig Sail at Large Attack Angles

open access: yesJournal of Marine Science and Engineering
Unmanned sailboats, harnessing wind for propulsion, offer great potential for extended marine research due to their virtually unlimited endurance. The sails typically operate at high attack angles, which contrasts with aircraft that maintain small angles
Qingsong Zeng, Wei Cai, Junhui Xu
doaj   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

open access: yesAdvanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan   +7 more
wiley   +1 more source

Analysis of the influence of different damage forms on the residual ultimate strength of ship structure

open access: yesZhongguo Jianchuan Yanjiu
ObjectivesShips are essential for waterborne transportation, and the safety of their structures is of utmost importance. However, during operation, ships may encounter various accidents such as collisions and groundings, which may damage the hull ...
Xiaoheng ZHANG   +2 more
doaj   +1 more source

Machine Learning‐Assisted Design and Performance Prediction of a Compact Dual‐Band Polarization‐Insensitive THz Metamaterial Absorber for Skin‐Cancer‐Related Refractive‐Index Sensing

open access: yesAdvanced Electronic Materials, EarlyView.
A compact QASRR‐based THz metamaterial absorber enables polarization‐insensitive dual‐band absorption and skin‐cancer‐related refractive‐index sensing through measurable resonance shifts. Field, surface‐current, and circuit analyses clarify the dual‐resonance mechanism, while StackNet‐assisted prediction accurately estimates the simulated absorption ...
Md. Murad Kabir Nipun   +5 more
wiley   +1 more source

Breaking the Polarity–Coordination Coupling in Electrolyte Design for High‐Voltage Lithium Batteries

open access: yesAdvanced Energy Materials, EarlyView.
Steric and electronic co‐regulation of 2,2,2‐trifluoro‐N, N‐dimethylethylamide (DMTFA) decouples high polarity from strong Li+ coordination, creating an anion‐mediated pseudo‐weakly solvating electrolyte. This design lowers Li+ desolvation barriers, enhances Li+ mobility, and builds B‐, F‐, and N‐rich inorganic interphases, enabling stable 3.0–4.6 V ...
Xue Li   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy