Results 51 to 60 of about 132,165 (308)
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
COVID-19 and the global cruise ship industry: potential recovery and reformation pathways
Bulletin of Geography. Socio-Economic Series, 2022 The cruise ship industry was one of the fastest growing subsectors of the tourism industry before the advent of COVID-19. This paper examines the prospects and recovery of the cruise ship industry from the devastating impacts of COVID-19 on the industry.
David Chikodzi +2 more
doaj +1 more source
Carbon dioxide emissions of Antarctic tourism [PDF]
, 2011 The increase of tourism to the Antarctic continent may entail not only local but also global environmental impacts. These latter impacts, which are mainly caused by transport, have been generally ignored.
Amelung, B. +7 more
core +2 more sources
Advanced Science, EarlyView.This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou +9 more
wiley +1 more source
A social network analysis of interconnections among cruise ports
Asian Journal of Shipping and Logistics, 2021 Despite the dominance of the Caribbean as the leading cruise destination in the world, research that focuses on the network of cruise ports in the region is limited.
Uriel Armando Lopez Rodriguez +3 more
doaj +1 more source
Maritime tourism and terrorism: Customer perceptions of the potential terrorist threat to cruise shipping [PDF]
, 2013 Maritime terrorism is a neglected area of research in tourism, particularly the use of scenario planning to understand potential threats to the cruise industry.
Bowen, C., Fidgeon, P., Page, S.J.
core +2 more sources
PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
Advanced Science, EarlyView.The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source
Strategic Management Journal, EarlyView., 2023 Abstract Research Summary Using detailed plant‐ and individual‐level data from a major Japanese cotton spinning company in the early 20th century, we examine the within‐firm allocation of skilled human capital in conjunction with investment in physical capital, accompanying the firm's evolving strategic priorities.
Shotaro Yamaguchi +3 more
wiley +1 more source
Le tourisme de croisière dans l’espace caribéen : évolutions récentes et enjeux de développement
Études Caribéennes, 2009 The Caribbean Sea is emblematic of the cruise, it is known for its international routes, scenic postcards touting the charms of the region. The analysis of the cruise industry will highlight some limits and contradictions of current development patterns.
Olivier Dehoorne +2 more
doaj +1 more source
Cruise ship suppliers: A field study of the supplier relationship characteristics in a service supply chain [PDF]
, 2015 The article of record as published may be found at http://dx.doi.org/10.1016/j.tmp.2015.07.008Given the significance of the service industry, the role of global service supply chains is becoming an important new area of research. This paper examines the
Beaulieu, Martin +2 more
core +1 more source