Results 191 to 200 of about 125,042 (305)

North Atlantic 2001 - Part 1 Cruise No. 50, Leg 1 7 May – 31 May 2001, Halifax – St. John’s [PDF]

open access: yes, 2002
Begler, Christian   +21 more
core  

Palaeolandscape reconstruction of a shallow coastal embayment in Kattegat, Denmark—influence of sea‐level changes during the latest Pleistocene and Holocene

open access: yesBoreas, EarlyView.
We analyse the geological processes of a coastal embayment in the Kattegat. Using high‐resolution seismic data and sediment cores, we describe a geological evolution from glacial to shallow marine stages with a variety of preserved facies from different depositional settings, including glacio‐lacustrine, telmatic, limnic and coastal environments.
Katrine Juul Andresen   +8 more
wiley   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche   +8 more
wiley   +1 more source

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng   +10 more
wiley   +1 more source

Bi-level Optimal Edge Computing Model for On-ramp Merging in Connected Vehicle Environment [PDF]

open access: yes, 2019
Ahn, Heejin   +6 more
core   +1 more source

What Linked Data Can Tell Us About the Increasing Numbers of Children Entering Public Care

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT The number of children in public care in Wales, UK, rose from the mid‐1990s to 2021. It is unclear if this change was related to increases in risk factors in parents, changes in the impact of risk factors, or changing policies and practices.
Nell Warner   +4 more
wiley   +1 more source

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