Results 41 to 50 of about 125,042 (305)

Alkaline Phosphatase‐Activated NIR‐II AIEgens Nanosystem for Surgical and Postoperative Closed‐Loop Therapy of Advanced Osteosarcoma

Advanced Science, EarlyView.
This study designed a tumor microenvironment‐responsive AIEgen nanoparticle for near‐infrared photoimmunotherapy, which inhibits primary tumors and metastasis by promoting pyroptosis and suppressing aerobic glycolysis. ABSTRACT In advanced osteosarcoma, tumor invasion often prevents complete resection, and immunotherapy is limited by the tumor's ...
Kaiyuan Liu, Ruotong Li, Li Zhang, Hengli Lu, Binhui Yang, Qian Hu, Yining Tao, Haoran Mu, Jing Han, Pengfei Zan, Jiakang Shen, Dongqing Zuo, Hongsheng Wang, Wei Sun, Xingjun Zhu   +14 more
wiley   +1 more source

Research Of Finite-time Event-triggered Control For High-speed Train Under Switching Topology

Journal of Applied Science and Engineering, 2022
A finite-time event-triggered model control strategy is proposed for multi-train high-speed train systems (MHSTs) with switching topologies. Due to the complexity of the high-speed railway operation environment, the communication topology of MHSTs is ...
Yunzhi Feng
doaj   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Design of intelligent cruise control system using fuzzy-PID control on autonomous electric vehicles prototypes

Journal of Mechatronics, Electrical Power, and Vehicular Technology
Electric vehicles provide a solution for using alternative fuels, namely, electricity. Electric vehicles are used for short distances and intercity travel over long distances, increasing the risk of accidents.
Joko Slamet Saputro, Miftahul Anwar, Feri Adriyanto, Agus Ramelan, Putra Maulana Yusuf, Fakih Irsyadi, Rendra Dwi Firmansyah, Tri Wahyu Oktaviana Putri   +7 more
doaj   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, EarlyView.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Improvement of Adaptive Cruise Control System Performance on Sloped Roads Based on Adaptive Neuro-Fuzzy Inference System

IEEE Access
Adaptive cruise control is a system that maintains an appropriate distance from vehicles ahead while driving. Although Adaptive cruise control systems operate stably on flat roads, they can become unstable on sloped roads. This study presents a method to
Kang-Hyeon Choi, Hyuk-Jun Chang
doaj   +1 more source

ADAS Impact Assessment by Micro-Simulation

European Journal of Transport and Infrastructure Research, 2001
This article presents the results of a ex-ante impact assessment study of Advanced Driver Assistance Systems. It focuses on two systems supporting longitudinal driving tasks, namely Autonomous Intelligent Cruise Control and Intelligent Speed Adaptation ...
S.P. Hoogendoorn, M.M. Minderhoud
doaj   +1 more source

Model-Based Reinforcement Learning for Eco-Driving Control of Electric Vehicles

IEEE Access, 2020
With the development of autonomous vehicles, research on energy-efficient eco-driving is becoming increasingly important. The optimal control problem of determining the speed profile of the vehicle for minimizing energy consumption is a challenging ...
Heeyun Lee, Namwook Kim, Suk Won Cha
doaj   +1 more source

Enhanced Responsivity, Accuracy, and Stability of Aerosol Jet Printing via Mechanical Switching Valve Assisted Internal Shuttering

Advanced Science, EarlyView.
This work demonstrates ultra‐high ON‐OFF responsivity of AJP by mechanical switching valve assisted shuttering. The jet relaxation and ON‐OFF delay are substantially eliminated from greater than 35 s, maintaining patterning quality independent of the variations of printing parameters, permitting excellent process stability and universality.
Jinhang Wang, Li Meng, Shuhuan Zhang, Pan Chen, Kaiwen Wei, Beibei Zhu, Xiaoyan Zeng   +6 more
wiley   +1 more source

Resource allocation and growth strategies in a multi‐plant firm: Kanegafuchi Spinners in the early 20th century

Strategic Management Journal, EarlyView., 2023
Abstract Research Summary Using detailed plant‐ and individual‐level data from a major Japanese cotton spinning company in the early 20th century, we examine the within‐firm allocation of skilled human capital in conjunction with investment in physical capital, accompanying the firm's evolving strategic priorities.
Shotaro Yamaguchi, Serguey Braguinsky, Tetsuji Okazaki, Takenobu Yuki   +3 more
wiley   +1 more source