Results 201 to 210 of about 46,881 (305)

Animal research in the UK: Regulation, implementation, welfare and development of new approach methodologies

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Scientific research with animals in the UK is regulated by the Animals (Scientific Procedures) Act 1986 with the National Centre for the Replacement, Refinement and Reduction of Animals in Research providing support for best practice and facilitating development of new approach methodologies.
Ewan St. John Smith   +6 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

open access: yesAngewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening

open access: yesAngewandte Chemie, EarlyView.
Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker   +3 more
wiley   +2 more sources

"If You're Willing to Work…We Can Work With You": Obligatory Labor at Residential Substance Use Services Providers in North Carolina. [PDF]

open access: yesSubst Use Misuse
Carroll JJ   +6 more
europepmc   +1 more source

Chandipura Virus Resurgence in India: Insights Into Diagnostic Tools, Antiviral Development, and Public Health Implications. [PDF]

open access: yesGlob Health Epidemiol Genom
Akingbola A   +8 more
europepmc   +1 more source

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