Results 181 to 190 of about 1,401 (256)

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Synthetic consciousness architecture. [PDF]

Front Robot AI
Spasokukotskiy K.
europepmc   +1 more source

Seasonal Fluctuations of Plastochromanol‐8 and α‐Tocopherol Amounts in the Leaves of Cecropia Trees

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Plastochromanol‐8 (PC‐8) is a homologue of γ‐tocotrienol with a longer side chain (eight instead of three isoprene units) and therefore also a representative of the tocochromanol (vitamin E) group. PC‐8 has been determined in various plants and seeds, with Cecropia sp. leaves showing unusually high levels.
Rosalie Ormos, Jörg Rau, Walter Vetter
wiley   +1 more source

A 5000-year overview of the history of pain through ancient civilizations to modern pain theories. [PDF]

Pain Rep
Vincenot M, Poisbeau P, Morel-Ferland N, Dumas G, Léonard G.   +4 more
europepmc   +1 more source

Long‐Time Thermal Aging of Perfluoroalkoxy Polymers for Electrical Insulation: Structural and Physical Properties Evolutions

Journal of Applied Polymer Science, EarlyView.
This work focuses on the investigation of the influence of a long‐time exposition to accelerated thermal aging on the physicochemical structure and properties of PFA. Results show a decrease in the melting temperature and crystal ratio due to chemical aging.
Victor Henri, Julien Chedaille, Pierre Henrard, Eric Dantras   +3 more
wiley   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

A Prospection‐Led Archaeological Investigation of a Picenian and Roman Necropolis in Corinaldo (Marche, Italy)

Archaeological Prospection, EarlyView.
ABSTRACT This paper presents the results of an integrated archaeological and geophysical investigation conducted between 2018 and 2024 at the newly discovered Picenian and Roman necropolis of Contrada Nevola (Corinaldo, Marche, Central Italy), identified in the framework of development‐led archaeology. The research strategy combined aerial photography,
Federica Boschi
wiley   +1 more source

Crusades

, 2016
Benjamin Z. Kedar, Jonathan Phillips, Jonathan Riley-Smith   +2 more
openaire   +3 more sources

Challenges and Opportunities in Multi‐Method Integrated Geophysical Prospection of Buried Building Remains at the Sanctuary of Olympia

Archaeological Prospection, EarlyView.
ABSTRACT Ancient Olympia was one of the most important sanctuaries and the venue for the Olympic Games in Greek and Roman times. Its remains are located in the Olympia Terrace (Peloponnese, Greece) at the present‐day confluence of the rivers Alpheios and Kladeos at the base of Mount Kronos.
Sarah Bäumler, Dennis Wilken, Peter Fischer, Lena Slabon, Timo Willershäuser, Birgitta Eder, Hans‐Joachim Gehrke, Erofili‐Iris Kolia, Franziska Lang, Oliver Pilz, Andreas Vött   +10 more
wiley   +1 more source

Genetic histories of individuals from multi-faith medieval Sicily. [PDF]

PLoS One
Monnereau A, Orecchioni P, Hamilton D, Green EJ, Noble I, Hagan R, Sandoval-Velasco M, Molinari A, Carver M, Speller CF, Wales N.   +10 more
europepmc   +1 more source