Results 201 to 210 of about 1,166,410 (270)

A Retrospctive Study of 377 Patients Admitted as an Emergency with Crush Syndrome After the Türkiye-Syria Earthquakes. [PDF]

Med Sci Monit
Görmeli Kurt N, Elmas Akgün F, İrem Mutlu R, Unutmaz M, Çamcı M.   +4 more
europepmc   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Kidney Replacement Therapies and Outcomes in Children With Crush Syndrome-Associated Kidney Injury.

JAMA Netw Open
Demirkol D, Besci T, Havan M, Karacanoglu D, Kihtir HS, Yildizdas D, Duyu M, Özel A, Kocaoglu DPY, Gökay N, Durak F, Misirlioglu M, Kilinç MA, Sincar S, Varol F, Köker A, Dalkiran T, Yaman A, Akçay N, Göncü S, Talip M, Akkuzu E, Uçmak H, Kendirli T, Barlas Koçoglu Ü, Tufan E, Çebisli E, Ekinci F, Kutlu NO, Kocaoglu Ç, Koç G, Alakayav M, Çolak M, Önder C, Güvenç KB, Ülgen Tekerek N, Dursun O, Aygüler E, Gençay AG, Bayrakçi B.   +39 more
europepmc   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Paving the way ahead: protocol optimization of mouse models in crush syndrome related acute kidney injury research. [PDF]

Front Pharmacol
Qiao O, Wang X, Li Z, Han L, Chen X, Zhang L, Bao F, Hao H, Hou Y, Duan X, Saeed S, Li N, Gong Y.   +12 more
europepmc   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Mortality Factors in Crush Syndrome. [PDF]

Ulus Travma Acil Cerrahi Derg
Onan E, Torun D, Kozanoğlu R, Miçözkadıoğlu H, Beyaz S, Özgözen L, Turgut N, Demiroğlu YZ, Karagün Ö, Ergenoğlu P, Kuşçu ÖÖ, Altan E, Güven AT, Abdullayev A, Karluka İ, Yalçın Ç, Mazıcan M, Balcı İG, Özkan B, Parmaksız G, Avcı B, Noyan A, Çolak T, Tünel HA, Temiz A, Gezer HÖ, Erdoğan C, Bairamoi G, Yünlüel D, Çivi S, Durdağ E, Kardeş Ö, Süner Hİ, Tufan K, Erkan S, Avcı T, Gündoğdu R, Kuş M, Fındıkçıoğlu A, Yıldız O, Alışkan E, Coşkunoğlu C, Haberal M.   +42 more
europepmc   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source