Results 71 to 80 of about 3,406,124 (331)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
ARQ (Santiago), 2002 Dos obras, horizontales y paralelas a la longitud del territorio chileno, dan cuenta de maneras distintas de situarse entre el valle central y la cordillera. Con maderas, una , y con una arquitectura blanca, la otra, apelan a la levedad y al arraigo respectivamente, y mediante la abstracción, median entre las múltiples dimensiones del acontecer de una ...
openaire +3 more sources
Consistence of a GL(3,R) gauge formulation for topological massive gravity
, 2007 We include a Chern-Simons term in a GL(3,R) gauge formulation of gravity with a cosmological contribution in 2+1 dimension and we explore consistence showing that excitations must be causal and standard topological massive gravity is recovered from this ...
Gaitan, Rolando
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
, 2015 The analysis of two zooarchaeological assemblages from Santa Cruz river mouth -Punta Entrada- (Patagonia Argentina) allows to postulate the past existence and human exploitation of sea lions ...
Isabel Cruz +6 more
semanticscholar +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
La permanencia del sacrificio de la Eucaristía
Estudios Eclesiásticos, 1972 El siguiente estudio habla sobre la Eucaristía como sacrificio. De forma concreta, se refiere a ella en su dimensión de permanencia vinculada al sagrario. El sacrificio se realiza en el acto de la consagración y se complementa con el de la comunión.
Emilio Sauras
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
O poder da linha na construção dos sentidos: uma análise a partir dos vários aspectos da cruz
Projetica, 2012 Este artigo apresenta um estudo sobre a cruz, uma das mais antigas formas criadas pelo homem, e discute seu conhecimento culturalmente produzido na consciência coletiva.
Mariana Oliveira de CARVALHO +1 more
doaj +1 more source
Ecumenismo desde los crucificados
Estudios Eclesiásticos, 1980 El presente estudio parte de la perspectiva latinoamericana, que antecede el acontecimiento histórico-salvífico a la sistematización conceptual, en este caso del ecumenismo.
Javier Jiménez Limón
doaj