Results 281 to 290 of about 6,313,615 (343)

An (αβ)2 Architecture of the Arabidopsis thaliana tRNA Splicing Endonuclease Complex: Structural Modeling and Evolutionary Analyses

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The tRNA splicing endonuclease (TSEN) removes introns from precursor tRNAs (pre‐tRNAs) in eukaryotes and archaea, but the architecture and subunit organization of plant TSEN remain poorly defined. Here, we integrated in planta bimolecular fluorescence complementation (BiFC) assays with AlphaFold3 (AF3)‐based structural modeling, molecular ...
Mohammad Moniruzzaman, Markus Englert, Kazuhito Akama   +2 more
wiley   +1 more source

A cryo-EM processing pipeline for microtubules using CryoSPARC. [PDF]

Acta Crystallogr D Struct Biol
Zhang D, Muñoz-Hernández H, Filipcik P, Sejwal K, Xu Y, Choi SR, Steinmetz MO, Wieczorek M.   +7 more
europepmc   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

The cryo-EM structure of bacteriophage PRR1 and its role in conjugation inhibition. [PDF]

J Virol
Lill Z, Thongchol J, Solis D, Zhang J.
europepmc   +1 more source

Deep Learning for Protein Secondary-Structure Segmentation in Intermediate-Resolution Cryo-EM Maps: A Resolution-Stratified Benchmark Dataset and Controlled Evaluation

Md Ehashan Rabbi Pial, Farhan Noor Dehan, Salim Sazzed   +2 more
openalex   +1 more source

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Cryo-EM structures of Candida albicans chitin synthase Chs1 reveal a druggable translocation channel. [PDF]

Nat Microbiol
Ren Z, Chhetri A, Liu C, Guan Z, Offner S, Kozhanov D, Borgnia MJ, Im W, Yokoyama K, Lee SY.   +9 more
europepmc   +1 more source

In situ cryo-EM reveals how a flagellar motor transmits high torque

Jian Yue, Wangbiao Guo, Md Khalesur Rahman, Hui Xu, Md Samiul Haque, Aaron Ye, Huaxin Yu, Jun Liu, MD A. MOTALEB   +8 more
openalex   +1 more source

Flavonoids From Sophora tonkinensis Disrupt STING‐TBK1‐IRF3 Complex Assembly and Ameliorate Inflammatory Diseases by Modulating cGAS‐STING Signaling

Phytotherapy Research, EarlyView.
STF attenuates the activation of the cGAS‐STING pathway by blocking the interactions between STING and IRF3 as well as between STING and TBK1, thereby exerting therapeutic effects against inflammatory diseases. ABSTRACT cGAS‐STING pathway is a core regulator of innate immunity and inflammatory responses. Aberrant activation of the cGAS‐STING pathway is
Jincai Wen, Yuanyuan Guo, Yingjie Xu, Guirong Zhang, Xianling Wang, Sida Song, Jinming Liu, Yijin Liu, Qiaodi Liu, Yi Hao, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai   +12 more
wiley   +1 more source

Cryo-EM insights into isoform-specific properties of the IP₃R2 channel. [PDF]

Nat Commun
Baker MR, Lin X, Fan G, Martinez-Chavez A, Wagner LE, Malik S, Allison T, Bell B, Seryshev AB, Cordero-Morales J, Baker ML, Yule DI, Serysheva II.   +12 more
europepmc   +1 more source