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Laboratory testing for cryoglobulins
American Journal of Hematology, 2011AbstractCryoglobulins are immunoglobulins that precipitate below 37°C and can cause multiorgan damage. There are three types of cryoglobulins: Type I (also called simple), which is mostly associated with monoclonal gammopathy and/or other hematologic disorders and Type II and Type III (known as mixed cryoglobulins), which are associated with infectious
Gabriela, Motyckova +1 more
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Chemical analyses of cryoglobulins
Immunochemistry, 1974Abstract A total of nine monoclonal cryoglobulins were subjected to chemical analyses. Results showed that they are preferentially associated with light chains with unblocked N-termini and also probably with heavy chain of VHI subgroup.
A.C. Wang +3 more
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Mixed Cryoglobulins and Glomerulonephritis
Annals of Internal Medicine, 1968Abstract The serum of a patient with rapidly progressive glomerulonephritis associated with mixed cryoglobulins showed sustained high levels of rheumatoid factors.
D, Golde, W, Epstein
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Clearance of cryoglobulins in man
Springer Seminars in Immunopathology, 1988From the foregoing it is evident that the defective clearance of immune complexes may contribute to tissue damage seen in patients with cryoglobulins. Hypocomplementaemia, decreased erythrocyte CR1, and the nature of the immune complexes may all contribute to decreased binding of immune complexes to erythrocytes with the potential consequence of ...
Y C, Ng, J A, Schifferli
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The investigation of cryoglobulins
Pathology, 1977In recent years the discovery of cryoglobulins has become increasingly frequent in a wide variety of disease states including multiple myeloma, acute and chronic infections, and immune complex diseases. However, proper collection of specimens is essential for their detection. In our laboratory, 10 ml clotted blood and 10 ml oxalated blood are taken and
A.E. Barr, B. Wan, A.E. Clague
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Cryoglobulins and cryoglobulinemia
Clinical Reviews in Allergy & Immunology, 1998Mixed cryoglobulinemia remains a major challenge to the clinician, both in terms of diagnosis and treatment. The discovery of its association with the hepatitis C virus has helped to shed light on the mechanisms of its pathogenesis and on how this complex disease might be managed.
Della Rossa A +2 more
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Cryoglobulin-induced inflammation
Agents and Actions, 1985Inflammation of the rat footpad followed injection of cryoglobulin in crystalline form (Type I) and injection of cryoglobulin in solution (Type II). Rats deficient in essential fatty acids responded with diminished swelling which corrected to normal levels by addition of prostaglandin E1 suggesting that this reaction is prostaglandin mediated. Addition
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Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection
2014The term cryoglobulinemia refers to the presence in the serum of one (monoclonal cryoimmunoglobulinemia) or more immunoglobulins (mixed cryoglobulinemia, MC), which precipitate at temperatures below 37 °C and redissolve on rewarming; this is an in vitro phenomenon. © 2014 Elsevier B.V. All rights reserved.
Ferri C. +4 more
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