Results 71 to 80 of about 4,377,931 (294)

Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation

Angewandte Chemie, EarlyView.
Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji, Chao Peng, Shuhan He, Bin‐Tao Peng, Wei‐Guang Wang, Yudai Matsuda   +5 more
wiley   +2 more sources

Genomic analysis reveals a cryptic pangolin species

Proceedings of the National Academy of Sciences, 2023
Eight extant species of pangolins are currently recognized. Recent studies found that two mitochondrial haplotypes identified in confiscations in Hong Kong could not be assigned to any known pangolin species, implying the existence of a species.
Tong-Tong Gu, Hong Wu, Feng Yang, Philippe Gaubert, Sean P. Heighton, Yeyizhou Fu, Ke Liu, Shu-Jin Luo, Hua-Rong Zhang, Jing-Yang Hu, Li Yu   +10 more
openaire   +3 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Deciphering Aspergillus section Terrei in Galleria mellonella model: a clade-specific pathogenicity characterization

Microbiology Spectrum
The Aspergillus genus encompasses a diverse array of species, some of which are opportunistic pathogens. Traditionally, human aspergillosis has primarily been linked to a few Aspergillus species, predominantly A. fumigatus.
Roya Vahedi-Shahandashti, Jos Houbraken, Vit Hubka, Martin Meijer, Bettina Gudrun Zelger, Ulrike Binder, Cornelia Lass-Flörl   +6 more
doaj   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

A practical implementation of large transcriptomic data analysis to resolve cryptic species diversity problems in microbial eukaryotes

BMC Evolutionary Biology, 2018
Background Transcriptome sequencing has become a method of choice for evolutionary studies in microbial eukaryotes due to low cost and minimal sample requirements.
Yonas I. Tekle, Fiona C. Wood
doaj   +1 more source

Cosmopolitan microbes and their ‘cryptic’ species [PDF]

Aquatic Microbial Ecology, 2005
The notion that microbial species have cosmopolitan distribution is discussed for protists in light of the considerable genetic variation within nominal species. It is concluded that there is no compelling evidence to indicate that different genotypes ('cryptic species') have biogeographies or that they originated through allopatric speciation.
openaire   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Multigene phylogeny and mating tests reveal three cryptic species related to Calonectria pauciramosa [PDF]

, 2010
Calonectria pauciramosa is a pathogen of numerous plant hosts worldwide. Recent studies have indicated that it included cryptic species, some of which are identified in this study.
Wingfield, Brenda D., Crous, Pedro W., Wingfield, Michael J., P.W. Crous, Crous, P.W., M.J. Wingfield, Wingfield, B.D., L. Lombard, B.D. Wingfield, Lombard, L., Wingfield, M.J., Lombard, Lorenzo   +11 more
core   +1 more source