Results 91 to 100 of about 12,984 (193)

A method for identifying alternative or cryptic donor splice sites within gene and mRNA sequences. Comparisons among sequences from vertebrates, echinoderms and other groups

BMC Genomics, 2009
Background As the amount of genome sequencing data grows, so does the problem of computational gene identification, and in particular, the splicing signals that flank exon borders.
Florea Liliana D, Buckley Katherine M, Smith L Courtney   +2 more
doaj   +1 more source

Endemic but not eroded: Genomic distinctiveness and conservation genomics of the British swallowtail butterfly (Papilio machaon britannicus)

Insect Conservation and Diversity, EarlyView.
Through whole‐genome sequencing of P. machaon populations across Europe, we demonstrate that P. m. britannicus forms a genetically distinct and isolated lineage. Demographic modelling revealed weak historical gene flow from the continent. Although P. m.
Benoit Nabholz, Eliette L. Reboud, Bérénice J. Lafon, Adam M. Cotton, Martin G. Partridge, N. Mark Collins, Fabien L. Condamine   +6 more
wiley   +1 more source

Optimized TadA‐derived base editors efficiently manipulate mRNA splicing by A‐to‐G and C‐to‐K editing in potato

Journal of Integrative Plant Biology, EarlyView.
Two optimized TadA‐derived base editors efficiently generate diverse splicing variants by targeting specific splice sites in potato. ABSTRACT Pre‐messenger RNA (pre‐mRNA) splicing is a critical mechanism for post‐transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate ...
Kaiyuan Chen, Yan Zhang, Jiuzhou Deng, Lumin Zhang, Huiying Zhou, Yaxin Duan, Enle Xiao, Guangtao Zhu, Chunzhi Zhang   +8 more
wiley   +1 more source

The (trans)national Russian religious imagination in exile: Iulia de Beausobre (1893‐1977)

Modern Theology, EarlyView.
Abstract The article offers a case study of how Russian Orthodox who migrated from the Soviet Union after the Bolshevik Revolution of 1917 reimagined their religious identity and their church in a transnational setting. Iulia de Beausobre (1893‐1977) was a Russian aristocrat who fell victim to the Stalinist purges but survived the Soviet prison system ...
Ruth Coates
wiley   +1 more source

City of God and the Duty of Just Memory

Modern Theology, EarlyView.
Abstract In a recent essay, Richard Miller claims that Augustine presumes a duty to remember justly in his City of God. However, Miller's brief reference to a presumed duty of “just memory” does not fully explain how Augustine conceptualizes this duty or how it relates to his theological concerns.
Zachary J. Taylor
wiley   +1 more source

The Judeo‐Islamic God

The Muslim World, EarlyView.
Abstract This article discusses the concept of the Judeo‐Islamic God as a substantive and defensible alternative to the problematic concept of the “Judeo‐Christian God” in popular, political, and academic Western discourses. It argues that the transcendent monotheistic deity of Islam, Allāh, is a direct continuation of the composite deity of Rabbinic ...
Jeffry R. Halverson
wiley   +1 more source

UniSplicer: A deep-learning framework for accurate splice-site prediction and splice-altering mutation detection across diverse taxa

Plant Communications
RNA splicing removes non-coding introns from pre-mRNA to generate mature mRNA in eukaryotes, and accurate identification of splice sites is essential for understanding gene structure and regulation.
Conghao Hong, Wenzhen Cheng, Zhengyi Li, Jiajie Deng, Yiqiong Li, Youyi Zang, Hongbo Gao   +6 more
doaj   +1 more source

A Severe Dementia Syndrome Caused by Intron Retention and Cryptic Splice Site Activation in STUB1 and Exacerbated by TBP Repeat Expansions. [PDF]

Front Mol Neurosci, 2022
Reis MC, Patrun J, Ackl N, Winter P, Scheifele M, Danek A, Nolte D.   +6 more
europepmc   +1 more source

“The future of death in the present of love”: Eros as an ethical pas encore in Levinas's Totality and Infinity

The Southern Journal of Philosophy, EarlyView.
Abstract This article reinterprets Levinas's account of ethical subjectivity by centering the temporality of the pas encore (“not yet”) and drawing on new materials in Œuvres complètes. I argue that, in Totality and Infinity, eros and ethics are internally continuous: eros generates a responsible not yet of time, secured by fecundity and oriented to ...
Huaiyuan Zhang
wiley   +1 more source

A novel cryptic splice donor due to synonymous variant in VPS13A as an underlying cause of a chorea-acanthocytosis in a large family

Heliyon
Chorea-acanthocytosis (ChAc) is a rare inherited disease of the nervous system. In this disease the neurological manifestations are associated with acanthocytosis of the red blood cells. The clinical features appear in the third to fourth decades of life.
Majed Alluqmani, Shahid Iqbal, Sulman Basit   +2 more
doaj   +1 more source