Results 31 to 40 of about 14,676 (218)
Journal of Cloud Computing: Advances, Systems and ApplicationsOwing to the emergence and rapid advances of new-generation information and digitalization technologies, the concept of model-driven digital twin has received widespread attentions and is developing vigorously.
Jiaxing Guo +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Circuit-noise-resilient virtual distillation
Communications PhysicsQuantum error mitigation (QEM) is vital for improving quantum algorithms’ accuracy on noisy near-term devices. A typical QEM method, called Virtual Distillation (VD), can suffer from imperfect implementation, potentially leading to worse outcomes than ...
Xiao-Yue Xu +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Pseudorandom number generators based on neural networks: a review
Journal of King Saud University: Computer and Information SciencesPseudorandom number generators are deterministic algorithms capable of producing sequences of numbers that appear sufficiently ”random,” and they find extensive applications across various domains such as cryptography, network security, communications ...
Xuguang Wu +6 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
PBSFL: Privacy-Preserving and Byzantine-Resilient for Summoning Federated Learning
Journal of King Saud University: Computer and Information SciencesWith the expansion of large-scale model applications, a typical division-of-labor federated learning (FL) training paradigm has emerged. This scenario is defined as Summoned Federated Learning (SFL), in which a single task initiator mobilizes cloud ...
Bowei Chen, Yan Ke, Wei Zhang, Jia Liu
doaj +1 more source