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Cryptotanshinone inhibits oral squamous cell carcinoma through the autophagic pathway
Neoplasma, 2023Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors with a low quality of life. Because traditional surgical treatment often causes large wounds and then affects the quality of life of patients, it is urgent to find new and efficient drugs with good safety for clinical treatment.
Xiao-Tian, Jiang, Ye, Qiu, Cong-Hua, Li
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Anticancer activity of cryptotanshinone on acute lymphoblastic leukemia cells
Archives of Toxicology, 2015Cryptotanshinone, a well-known diterpene quinone from a widely used traditional Chinese herb named Salvia miltiorrhiza, has been reported for its therapeutical potentials on diverse activities. In this study, pharmacological effects of cryptotanshinone on acute lymphoblastic leukemia cells were investigated.
Ching-Fen, Wu +2 more
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Cryptotanshinone inhibits human glioma cell proliferation by suppressing STAT3 signaling
Molecular and Cellular Biochemistry, 2013Malignant gliomas (MGs) are among the most aggressive types of cancers in the human brain. Frequent tumor recurrence caused by a lack of effective therapeutic approaches results in a poor prognosis. Signal transducer and activator of transcription 3 (STAT3), an oncogenic protein, is constitutively activated in MGs and predicts a poor clinical outcome ...
Liang, Lu +9 more
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Cryptotanshinone: A review of its pharmacology activities and molecular mechanisms
Fitoterapia, 2020As a natural quinone compound, the medicinal value of cryptotanshinone (CT) has received increasing attentions, but there is no systematic literature review that describes the pharmacological activity of CT. This paper reviewed the pharmacology researches of CT, with a primary focus on its anti-tumor activity. We also discussed the underlying molecular
Yan-Hong, Wu +3 more
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Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression
European Journal of Pharmacology, 2006Cyclooxygenase-2 (COX-2) is a key enzyme that catalyzes the biosynthesis of prostaglandins from arachidonic acid and plays a critical role in some pathologies including inflammation, neurodegenerative diseases and cancer. Cryptotanshinone is a major constituent of tanshinones, which are extracted from the medicinal herb Salvia miltiorrhiza Bunge, and ...
Dao-Zhong, Jin +3 more
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The prevention effects of cryptotanshinone nanoemulsion on postoperative peritoneal adhesions
Drug Development and Industrial Pharmacy, 2019The purpose of this study was to prepare a novel cryptotanshinone-loaded nanoemulsion (Cry LN) and to evaluate its prevention effect on the postoperative peritoneal adhesions (PPA). The Cry LN was prepared by high-pressure homogenization method, and various methods were used to investigate the physicochemical properties.
Wang Chengxi +5 more
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Journal of Cardiovascular Pharmacology, 2021
Abstract: Chinese people have used the root of Salvia miltiorrhiza Bunge (called “Danshen” in Chinese) for centuries as an anticancer agent, anti-inflammatory agent, antioxidant, and cardiovascular disease drug. In addition, Danshen is considered to be a drug that can improve ischemia/reperfusion (I/R)-induced myocardium injury in traditional
Hefeng, Wang +5 more
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Abstract: Chinese people have used the root of Salvia miltiorrhiza Bunge (called “Danshen” in Chinese) for centuries as an anticancer agent, anti-inflammatory agent, antioxidant, and cardiovascular disease drug. In addition, Danshen is considered to be a drug that can improve ischemia/reperfusion (I/R)-induced myocardium injury in traditional
Hefeng, Wang +5 more
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Abstract 5269: Cryptotanshinone activate Nrf2 expression through microRNA regulations
Cancer Research, 2017Abstract Cryptotanshinone is a diterpene quinone derived from the roots of Salvia miltiorrhiza Bunge. An increasing number of studies have demonstrated that cryptotanshinone has the pharmacological activities such as anti-oxidative stress, anti-bacteria, anti-inflammation, and anti-cancer.
Rachmad A. Dongoran, Tien-Yuan Wu
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Formulation study on cryptotanshinone gel for topical administration
China Journal of Chinese Materia Medica, 2010OBJECTIVE To screen the formulations of cryptotanshinone gel for treatment of topical diseases such as acne. METHOD Different cryptotanshinone gels incorporating various penetration enhancers at different concentrations were prepared using carbopol 934L as matrix.
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Cryptotanshinone induces ER stress-mediated apoptosis in HepG2 and MCF7 cells
Apoptosis, 2011The endoplasmic reticulum (ER) is a central organelle in eukaryotic cells that functions in protein synthesis and maturation, and also functions as a calcium storage organelle. Perturbation of ER functions leads to ER stress, which has been previously associated with a broad variety of diseases.
In-Ja, Park +6 more
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