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Mechanisms of the dilator action of cryptotanshinone on rat coronary artery
European Journal of Pharmacology, 2008In this study, we have investigated the actions of cryptotanshinone, an active, lipophilic component of the medicinal herb danshen (Salvia miltiorrhiza), on rat isolated coronary artery rings precontracted with 1 microM 5-hydroxytryptamine (5-HT) and its action compared to the ethanol-extractable fraction of the herb.
Francis F Y, Lam +3 more
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The prevention effects of cryptotanshinone nanoemulsion on postoperative peritoneal adhesions
Drug Development and Industrial Pharmacy, 2019The purpose of this study was to prepare a novel cryptotanshinone-loaded nanoemulsion (Cry LN) and to evaluate its prevention effect on the postoperative peritoneal adhesions (PPA). The Cry LN was prepared by high-pressure homogenization method, and various methods were used to investigate the physicochemical properties.
Wang Chengxi +5 more
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In Silico Modeling of the Induction of Apoptosis by Cryptotanshinone in Osteosarcoma Cell Lines
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2022Osteosarcoma (OS) is the most common primary malignant bone tumor of both children and pet canines. Its characteristic genomic instability and complexity coupled with the dearth of knowledge about its etiology has made improvement in the current treatment difficult.
Radhika Saraf +7 more
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Anticancer activity of cryptotanshinone on acute lymphoblastic leukemia cells
Archives of Toxicology, 2015Cryptotanshinone, a well-known diterpene quinone from a widely used traditional Chinese herb named Salvia miltiorrhiza, has been reported for its therapeutical potentials on diverse activities. In this study, pharmacological effects of cryptotanshinone on acute lymphoblastic leukemia cells were investigated.
Ching-Fen, Wu +2 more
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A Review of Cryptotanshinone and its Nanoformulation in Cancer Therapy
Anti-Cancer Agents in Medicinal ChemistryCancer, with a high incidence and mortality rate, has emerged as a major public health problem worldwide. Currently, new approaches, such as targeted therapy and immunotherapy, are giving hope to patients. However, drug resistance and adverse side effects are major barriers to cancer treatment. As a result, there is a greater focus on the development
Xin, Liu +8 more
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PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA
Chemico-Biological Interactions, 2009Danshen (Radix Salvia miltiorrhiza) is a famous Traditional Chinese Medicine used widely for the treatment of coronary heart disease and cerebrovascular disease. Diterpenoid tanshinones including tanshinone I, tanshinone IIA and cryptotanshinone are the major bioactive components from Danshen herb.
Chunna, Yu +7 more
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Salvia miltiorrhiza: In Vitro Production of Cryptotanshinone and Ferruginol
1989Salvia miltiorrhiza Bunge (Labiatae), growing wild in China, is a perennial herb (Fig. 1), 30 to 80 cm high, and the root of this plant, called Tan-shen in Chinese and Tan-jin in Japanese, is an ancient Chinese drug, ranked as a super-grade medicine in “Shen-nung-pen-tsao-ching”, the oldest classical Chinese herbal. It has been widely used in China for
H. Miyasaka, M. Nasu, K. Yoneda
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Formulation study on cryptotanshinone gel for topical administration
China Journal of Chinese Materia Medica, 2010OBJECTIVE To screen the formulations of cryptotanshinone gel for treatment of topical diseases such as acne. METHOD Different cryptotanshinone gels incorporating various penetration enhancers at different concentrations were prepared using carbopol 934L as matrix.
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Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression
European Journal of Pharmacology, 2006Cyclooxygenase-2 (COX-2) is a key enzyme that catalyzes the biosynthesis of prostaglandins from arachidonic acid and plays a critical role in some pathologies including inflammation, neurodegenerative diseases and cancer. Cryptotanshinone is a major constituent of tanshinones, which are extracted from the medicinal herb Salvia miltiorrhiza Bunge, and ...
Dao-Zhong, Jin +3 more
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Studies on the spectroscopic behavior of cryptotanshinone, tanshinone IIA, and tanshinone I
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2004A comparative study on the spectroscopic behavior of cryptotanshinone (CTan), tanshinone IIA (Tan IIA), and tanshinone I (Tan I) has been investigated, including UV-Vis absorption, low temperature phosphorescence (LTP), low temperature fluorescence (LTF), paper substrate-room temperature phosphorescence (PS-RTP), paper substrate-room temperature ...
Jun-Fen, Li +4 more
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