Tanshinone-I for the treatment of uterine fibroids: Molecular docking, simulation, and density functional theory investigations [PDF]
Saudi Pharmaceutical Journal, 2023 Uterine fibroids (UF), most prevalent gynecological disorder, require surgery when symptomatic. It is estimated that between 25 and 35 percent of women wait until the symptoms have worsened like extended heavy menstrual bleeding and severe pelvic pain ...
Abhishek Tiwari +12 more
doaj +3 more sources
Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives [PDF]
Natural Products and BioprospectingNatural product tanshinone I exhibits weak potency and poor drug-like properties, which have restricted its clinical development as an anticancer agent.
Huimin Zhao +9 more
doaj +4 more sources
Monoamine Oxidase Inhibition by Major Tanshinones from Salvia miltiorrhiza and Selective Muscarinic Acetylcholine M4 Receptor Antagonism by Tanshinone I [PDF]
Biomolecules, 2021 Monoamine oxidases (MAOs) and muscarinic acetylcholine receptors (mAChRs) are considered important therapeutic targets for Parkinson’s disease (PD). Lipophilic tanshinones are major phytoconstituents in the dried roots of Salvia miltiorrhiza that have ...
Ritu Prajapati +6 more
doaj +6 more sources
Tanshinone I improves renal fibrosis by promoting gluconeogenesis through upregulation of peroxisome proliferator-activated receptor-γ coactivator 1α [PDF]
Renal FailureBackground Renal fibrosis, a hallmark of chronic kidney disease, is closely associated with dysregulated gluconeogenesis. Tanshinone I (Tan I), a bioactive compound derived from the traditional Chinese medicine Danshen, exhibits antifibrotic and anti ...
Yanfang Bai +7 more
doaj +3 more sources
Research and Development of Natural Product Tanshinone I: Pharmacology, Total Synthesis, and Structure Modifications [PDF]
Frontiers in Pharmacology, 2022 Salvia miltiorrhiza (S. miltiorrhiza), which has been used for thousands of years to treat cardiovascular diseases, is a well-known Chinese medicinal plant. The fat-soluble tanshinones in S.
Xing Huang +7 more
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Tanshinone I suppresses hepatocellular carcinoma cells growth through targeting DNA double-strand break repair [PDF]
Cancer Biology & Therapy, 2023 Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumors with increasing incidence rates and high mortality rates. The currently available methods for treating HCC include surgery, radiotherapy or chemotherapy, but all of them ...
Zhen Qian, Nannan Feng, Anke Geng
doaj +2 more sources
Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate Staphylococcus aureus pathogenicity [PDF]
VirulenceStaphylococcus aureus (S. aureus) is a prevalent pathogen responsible for a wide range of diseases in humans, contributing to both hospital-acquired and community-acquired infections.
Shiyu Zhou +9 more
doaj +2 more sources
Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation [PDF]
Drug Design, Development and TherapyQiao Wang,1,* Xin Luo,1,* Yuwen Su,1 Yi Jin,1 Qiqi Kuang,1 Siying Li,1 Weiyun Shen,2 Yanshan Zhu1 1Department of Dermatology, Second Xiangya Hospital, Hunan Key Laboratory of Medical Epigenomics, Clinical Medical Research Center of Major Skin ...
Wang Q +7 more
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Multi-omics elucidation of temporal patterns in tanshinone accumulation in Salvia miltiorrhiza [PDF]
BMC Plant BiologySalvia miltiorrhiza is valued for tanshinones, but the dynamics and regulatory mechanisms of tanshinone accumulation from root expansion to harvest are unclear.
Mingzhi Zhong +11 more
doaj +2 more sources
Local Sodium Tanshinone IIA Sulfonate Attenuates Periodontal Bone Loss by Modulating Inflammatory, Immune and Osteoclastogenic Signalling. [PDF]
J Clin PeriodontolABSTRACT Aim To investigate whether local administration of sodium tanshinone IIA sulfonate (STS) modulates periodontal inflammation, alveolar bone loss, immune response and bone remodelling–related signalling pathways in a ligature‐induced murine model of periodontitis.
de Molon RS +11 more
europepmc +2 more sources