The Skeletal Effects of Tanshinones: A Review
Molecules, 2021 Background: Osteoporosis results from excessive bone resorption and reduced bone formation, triggered by sex hormone deficiency, oxidative stress and inflammation.
Kok-Yong Chin +2 more
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Tanshinones, Critical Pharmacological Components in Salvia miltiorrhiza [PDF]
Frontiers in Pharmacology, 2019 Salvia miltiorrhiza Bunge, a member of the Lamiaceae family, is valued in traditional Chinese Medicine. Its dried root (named Danshen) has been used for hundreds of years, primarily for the treatment of cardiovascular and cerebrovascular diseases ...
Wei Gao
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Therapeutic Potential of Tanshinones in Osteolytic Diseases: From Molecular and Cellular Pathways to Preclinical Models [PDF]
Dentistry JournalTanshinones are a class of lipophilic diterpenoid quinones extracted from Salvia miltiorrhiza (Dan shen), a widely used herb in traditional Chinese medicine. These compounds, particularly tanshinone IIA (T-IIA) and sodium tanshinone sulfonate (STS), have
Rafael Scaf de Molon
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Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones [PDF]
Asian Journal of Pharmaceutical Sciences, 2017 Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge. Tanshinone IIA and cryptotanshinone are the major components in total tanshinones.
Charlie C Xue +2 more
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Frontiers in Plant Science, 2018 Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of cardiovascular diseases. WRKYs play important roles in plant metabolism, but their regulation mechanism in Salvia miltiorrhiza remains elusive.
Guoyin Kai, Xiaolong Hao, Min Shi
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The Biosynthetic Pathways of Tanshinones and Phenolic Acids in Salvia miltiorrhiza
Molecules, 2015 Secondary metabolites from plants play key roles in human medicine and chemical industries. Due to limited accumulation of secondary metabolites in plants and their important roles, characterization of key enzymes involved in biosynthetic pathway will ...
Juan Guo, Guang-Hong Cui
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The effect of tanshinones on cognitive impairments in animal models of Alzheimer’s disease: a systematic review and meta-analysis [PDF]
Frontiers in PharmacologyBackgroundAlzheimer’s disease (AD) is an age-related neurological illness that poses a significant hazard to human health. A fat-soluble compound called tanshinones was isolated from Danshen, a traditional Chinese herb.
Shuwei Wang +7 more
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Smi-miR164a positively regulates phenolic acid biosynthesis while negatively regulates tanshinone production in Salvia miltiorrhiza [PDF]
Frontiers in Plant ScienceIntroductionMicroRNAs (miRNAs) are key post-transcriptional regulators of plant secondary metabolism. Their primary mechanism involves silencing target genes through mRNA cleavage or translational inhibition, which is a major focus of current research in
Huaqian You +4 more
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The Anticancer Properties of Tanshinones and the Pharmacological Effects of Their Active Ingredients
Frontiers in Pharmacology, 2020 Cancer is a common malignant disease worldwide with an increasing mortality in recent years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the treatment of cardiovascular and cerebrovascular diseases for thousands of ...
Gopal Patel, Guoyin Kai
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Comparative efficacy of sweated and non-sweated Salvia miltiorrhiza Bge. extracts on acute myocardial ischemia via regulating the PPARα/RXRα/NF-κB signaling pathway [PDF]
HeliyonSalvia miltiorrhiza Bge. (S. miltiorrhiza) is a well-known traditional Chinese medicine for the treatment of cardiovascular diseases. The processing of S. miltiorrhiza requires the raw herbs to sweat first and then dry.
Xiaoxiao Shan +10 more
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