Results 41 to 50 of about 2,182 (156)

HPLC traces of the combinatorial modified tanshinones extract highlighting the minor but active compound 10 (A), and total tanshinones of Salvia miltiorrhiza highlighting the three major natural tanshinones (B).

, 2014
HPLC traces of the combinatorial modified tanshinones extract highlighting the minor but active compound 10 (A), and total tanshinones of Salvia miltiorrhiza highlighting the three major natural tanshinones (B).
Ai-Lin Liu (592284), Hai-Yan Tian (536638), Ren-Wang Jiang (448625), Shang Li (362882), Wen-Cai Ye (303536), Jin-Hang Li (592283), Pui-Man Hoi (592285), Simon Ming-Yuen Lee (545654), Zhe-Rui Zhang (592282)   +8 more
core   +1 more source

Expansion within the CYP71D subfamily drives the heterocyclization of tanshinones synthesis in Salvia miltiorrhiza [PDF]

, 2021
Tanshinones are the bioactive nor-diterpenoid constituents of the Chinese medicinal herb Danshen (Salvia miltiorrhiza). These groups of chemicals have the characteristic furan D-ring, which differentiates them from the phenolic abietane-type diterpenoids
Kang, Liping, Zhao, Yujun, Qi, Xiaoquan, Wang, Ruishan, Jin, Baolong, Ma, Ying, Peters, Reuben J., Wang, Yanan, Huang, Luqi, Tang, Jinfu, Yang, Jian, Ma, Xiaohui, Cui, Guanghong, Zeng, Wen, Shen, Ye, Lai, Changjiangsheng, Guo, Juan, Peters, Reuben, Chen, Tong   +18 more
core   +1 more source

Cytotoxic diterpenoids from Salvia glutinosa and comparison with the tanshinone profile of danshen (Salvia miltiorrhiza)

Frontiers in Plant Science, 2023
The roots of Salvia miltiorrhiza are the source of the traditional Chinese medicine danshen and the class of tanshinones, particular quinoid nor-diterpenoids of the abietane type.
Arpine Ayvazyan, Lenard Deutsch, Lenard Deutsch, Christian Zidorn, Brigitte Kircher, Brigitte Kircher, Serhat S. Çiçek, Serhat S. Çiçek   +7 more
doaj   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

DataSheet_1_SmGRAS1 and SmGRAS2 Regulate the Biosynthesis of Tanshinones and Phenolic Acids in Salvia miltiorrhiza.docx

, 2019
Salvia miltiorrhiza is one of the most widely used traditional Chinese medicinal plants because of its excellent performance in treating heart diseases.
Dongfeng Yang (185887), Tianlin Pei (7578146), Zhenqing Bai (3753301), Renjun Mao (4569448), Chuangfeng Liu (7578152), Wenrui Li (702506), Bingxue Zhang (7578149), Zongsuo Liang (185893)   +7 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

SmEIL1 transcription factor inhibits tanshinone accumulation in response to ethylene signaling in Salvia miltiorrhiza

Frontiers in Plant Science
Among the bioactive compounds, lipid-soluble tanshinone is present in Salvia miltiorrhiza, a medicinal plant species. While it is known that ethephon has the ability to inhibit the tanshinones biosynthesis in the S.
Xiujuan Li, Man Xu, Ke Zhou, Siyu Hao, Liqin Li, Leran Wang, Wei Zhou, Guoyin Kai   +7 more
doaj   +1 more source

In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

Biomolecules, 2022
Tanshinone IIA (TIIA) and cryptotanshinone (CRY) from Salvia miltiorrhiza Bunge were investigated for their inhibitory activity against the cyclooxygenase-2 (COX-2)/microsomal prostaglandin E synthase-1 (mPGES-1)/endothelial prostaglandin 3 (EP3) pathway
Anella Saviano, Simona De Vita, Maria Giovanna Chini, Noemi Marigliano, Gianluigi Lauro, Gian Marco Casillo, Federica Raucci, Maria Iorizzi, Robert Klaus Hofstetter, Katrin Fischer, Andreas Koeberle, Oliver Werz, Francesco Maione, Giuseppe Bifulco   +13 more
doaj   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source