Results 21 to 30 of about 2,991 (214)

Tanshinone I, tanshinone IIA, and cryptotanshinone: key bioactive components modulating vascular smooth muscle cell function. [PDF]

Front Pharmacol
Cardiovascular diseases (CVDs) remain the leading cause of mortality among non-communicable diseases worldwide. Vascular smooth muscle cells (VSMCs), as the predominant cellular component of the tunica media, are essential for maintaining vascular homeostasis through phenotype-dependent regulation of vascular tone, blood pressure, and hemodynamics ...
Li J, Wang W, Huang H, Zhou R, Yang Z, Cui Z, Niu Z, Shi S, Wang P.   +8 more
europepmc   +2 more sources

Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB

Biomedicine & Pharmacotherapy, 2021
Mastitis is a common disease occurs in breast-feeding mothers, but published data are poor. This study aimed to study the effects of Tanshinones on treating mastitis.Clinical trials performed in 58 breast-feeding mothers were carried out. B-ultrasound and blood test were used to measure the size of breast mass and the change of blood cell counts.
Lili, Yang, Guanglin, Zhou, Jinghua, Liu, Jinshuang, Song, Zongyu, Zhang, Qi, Huang, Fengxiang, Wei   +6 more
openaire   +2 more sources

SmGRAS1 and SmGRAS2 Regulate the Biosynthesis of Tanshinones and Phenolic Acids in Salvia miltiorrhiza

Frontiers in Plant Science, 2019
Salvia miltiorrhiza is one of the most widely used traditional Chinese medicinal plants because of its excellent performance in treating heart diseases.
Wenrui Li, Wenrui Li, Zhenqing Bai, Tianlin Pei, Dongfeng Yang, Renjun Mao, Bingxue Zhang, Bingxue Zhang, Chuangfeng Liu, Zongsuo Liang, Zongsuo Liang   +10 more
doaj   +1 more source

Combining Metabolomics and Transcriptomics to Characterize Tanshinone Biosynthesis in Salvia Miltiorrhiza [PDF]

, 2014
Plant natural products have been co-opted for millennia by humans for various uses such as flavor, fragrances, and medicines. These compounds often are only produced in relatively low amounts and are difficult to chemically synthesize, limiting access ...
Cui, Guanghong, Gao, Wei, Hillwig, Matthew L, Huang, Luqi, Jackson, Alana, Peters, Reuben J, Shen, Ye, Sun, Hai-Xi, Wang, Xiao, Wang, Xiu-Jie, Xiao, Hongbin, Zhang, Liangxiao, Zhao, Nan   +12 more
core   +3 more sources

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects [PDF]

, 2015
Chronic liver dysfunction or injury is a serious health problem worldwide. Chronic liver disease involves a wide range of liver pathologies that include fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma.
Feng, Y, HONG, M, LI, S, TAN, HY, Tsao, GSW, Wang, N   +5 more
core   +8 more sources

Mechanism of tanshinones and phenolic acids from Danshen in the treatment of coronary heart disease based on co-expression network

BMC Complementary Medicine and Therapies, 2020
Background The tanshinones and phenolic acids in Salvia miltiorrhiza (also named Danshen) have been confirmed for the treatment of coronary heart disease (CHD), but the action mechanisms remain elusive.
Dongxue Wu, Mengqi Huo, Xi Chen, Yanling Zhang, Yanjiang Qiao   +4 more
doaj   +1 more source

Experimental and modeling studies on microwave-assisted extraction of mangiferin from Curcuma amada [PDF]

, 2013
Mangiferin, a bioactive compound having potent nutraceutical, strong antioxidant and pharmacological significance has been extracted using microwave-assisted extraction (MAE) technique from Curcuma amada, commonly known as mango ginger.
Chaudhuri, Surabhi, Constales, Denis, Dutta, Abhishek, Dutta, Debjani, Kullu, Jeke   +4 more
core   +1 more source

Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]

, 2020
Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I, Tabish, Tanveer A, Whatmore, Jacqueline L, Zhang, Shaowei   +3 more
core   +2 more sources

Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish [PDF]

Molecules, 2012
The study aimed to investigate the potential of zebrafish in imitating mammal phase I metabolism of natural compounds. Three diterpenoid quinones from Radix Salvia miltiorrhiza, namely tanshinone IIA (TIIA), cryptotanshinone (Cry) and tanshinone I (TI) were selected as model compounds, and their metabolites mediated by zebrafish were characterized ...
Bing Wang, Xiaobin Jia, Luan Shu, Yunru Peng, Changmei Wang, Ping Li, Yingjie Wei, Wenquan Ma   +7 more
openaire   +3 more sources

Effects of Combined Elicitors on Tanshinone Metabolic Profiling and SmCPS Expression in Salvia miltiorrhiza Hairy Root Cultures

Molecules, 2013
Tanshinones are abietane-type norditerpenoid quinone natural products found in a well-known traditional Chinese medicinal herb, Salvia miltiorrhiza Bunge. The copalyl diphosphate synthase of S. miltiorrhiza (SmCPS) is the key enzyme in the first step for
Yujia Liu, Wei Gao, Geng Li, Yunfei He, Qiqing Cheng, Luqi Huang   +5 more
doaj   +1 more source