Results 1 to 10 of about 7,215 (115)

Recent advances of tanshinone in regulating autophagy for medicinal research

open access: yesFrontiers in Pharmacology, 2023
Initially described as an ancient and highly conserved catabolic biofunction, autophagy plays a significant role in disease pathogenesis and progression.
Sha Wu   +18 more
doaj   +1 more source

Combination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone

open access: yesDrug Delivery, 2021
Prostate cancer is the second most frequently diagnosed cancer in the men population. Combination anticancer therapy using doxorubicin (DOX) and another extract of traditional Chinese medicine is one nano-sized drug delivery system promising to generate ...
Guanxing Sun, Kai Sun, Jie Sun
doaj   +1 more source

Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation

open access: yesPharmaceutical Biology, 2021
Context Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain.
Lijie Liu   +5 more
doaj   +1 more source

PPARG is a potential target of Tanshinone IIA in prostate cancer treatment: a combination study of molecular docking and dynamic simulation based on transcriptomic bioinformatics

open access: yesEuropean Journal of Medical Research, 2023
Tanshinone IIA is a lipophilic organic compound from the root of Danshen (Salvia miltiorrhiza) and is one of the most well-known Tanshinone molecules by pharmacologists.
Tongtong Zhang   +7 more
doaj   +1 more source

Research and Development of Natural Product Tanshinone I: Pharmacology, Total Synthesis, and Structure Modifications

open access: yesFrontiers in Pharmacology, 2022
Salvia miltiorrhiza (S. miltiorrhiza), which has been used for thousands of years to treat cardiovascular diseases, is a well-known Chinese medicinal plant. The fat-soluble tanshinones in S.
Xing Huang   +7 more
doaj   +1 more source

Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells. [PDF]

open access: yesPLoS ONE, 2016
Tanshinone IIA, one of the most pharmacologically bioactive phytochemicals isolated from Salvia miltiorrhiza Bunge, possesses several biological activities such as anti-inflammation, anti-cancer, neuroprotection and hypolipidemic activities.
Hung-Chen Chen   +4 more
doaj   +1 more source

Nano-encapsulated tanshinone IIA in PLGA-PEG-COOH inhibits apoptosis and inflammation in cerebral ischemia/reperfusion injury

open access: yesGreen Processing and Synthesis, 2023
Tanshinone IIA has a potential therapeutic effect on cerebral ischemia/reperfusion injury (CIRI). In this study, tanshinone IIA was encapsulated in poly(lactic-co-glycolic acid)-block-poly (ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) nanoparticles ...
Zhang Xin   +7 more
doaj   +1 more source

A Skin Lipidomics Study Reveals the Therapeutic Effects of Tanshinones in a Rat Model of Acne

open access: yesFrontiers in Pharmacology, 2021
Tanshinone (TAN), a class of bioactive components in traditional Chinese medicinal plant Salvia miltiorrhiza, has antibacterial and anti-inflammatory effects, can enhance blood circulation, remove blood stasis, and promote wound healing.
Tingting Chen   +13 more
doaj   +1 more source

Tanshinone IIA changed the amniotic fluid volume and regulated expression of AQP1 and AQP3 in amniotic epithelium cells: a promising drug treating abnormal amniotic fluid volume

open access: yesMolecular Medicine, 2023
Background Many studies have confirmed the association of aquaporins (AQPs) with abnormal amniotic fluid volume (AFV). In our previous experiments, we found that Tanshinone IIA was able to regulate the expression of AQP1 and AQP3.
Shuangjia Pan   +5 more
doaj   +1 more source

Cytotoxic diterpenoids from Salvia glutinosa and comparison with the tanshinone profile of danshen (Salvia miltiorrhiza)

open access: yesFrontiers in Plant Science, 2023
The roots of Salvia miltiorrhiza are the source of the traditional Chinese medicine danshen and the class of tanshinones, particular quinoid nor-diterpenoids of the abietane type.
Arpine Ayvazyan   +7 more
doaj   +1 more source

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