Results 11 to 20 of about 7,215 (115)

Multi-omics elucidation of temporal patterns in tanshinone accumulation in Salvia miltiorrhiza [PDF]

BMC Plant Biology
Salvia miltiorrhiza is valued for tanshinones, but the dynamics and regulatory mechanisms of tanshinone accumulation from root expansion to harvest are unclear.
Mingzhi Zhong, Fang Peng, Jian Yang, Can Yuan, Hailang Liao, Xiufu Wan, Long Zhou, Changqing Mao, Xinyi Zhao, Song Chen, Chao Zhang, Shan Tao   +11 more
doaj   +2 more sources

Local Sodium Tanshinone IIA Sulfonate Attenuates Periodontal Bone Loss by Modulating Inflammatory, Immune and Osteoclastogenic Signalling [PDF]

Journal of Clinical Periodontology, Volume 53, Issue 9, Page 1443-1458, September 2026.
ABSTRACT Aim To investigate whether local administration of sodium tanshinone IIA sulfonate (STS) modulates periodontal inflammation, alveolar bone loss, immune response and bone remodelling–related signalling pathways in a ligature‐induced murine model of periodontitis.
Rafael Scaf de Molon, Raquel Mantuaneli Scarel‐Caminaga, François Isnaldo Dias Caldeira, Edilson Ervolino, Erica Dorigatti de Avila, Paula Aboud Barbugli, Gabriela Ezequiel Oliveira, Joao Pedro Franco‐Moura, Leticia Helena Theodoro, Joni Augusto Cirelli, Sotirios Tetradis, Alpdogan Kantarci   +11 more
wiley   +2 more sources

Improving the Stability of Transfersome Systems by Co-Encapsulating Components of Varying Hydrophobicity [PDF]

Pharmaceutics
Background: As a novel drug delivery vehicle, transfersomes (TFSs) have great deformability, good biocompatibility, and biodegradability, which can significantly improve drug delivery efficiency.
Xin Shen, Mian Zhao, Muhammad Hamza, Wen-Ting Wu, Jing Liu, Zi-Lu Guo, Zhi-Yu Guan, Zhe Li, Wei-Feng Zhu   +8 more
doaj   +2 more sources

Methyl Jasmonate Activates the 2C Methyl-D-erithrytol 2,4-cyclodiphosphate Synthase Gene and Stimulates Tanshinone Accumulation in Salvia miltiorrhiza Solid Callus Cultures

Molecules, 2022
The present study characterizes the 5′ regulatory region of the SmMEC gene. The isolated fragment is 1559 bp long and consists of a promoter, 5′UTR and 31 nucleotide 5′ fragments of the CDS region. In silico bioinformatic analysis found that the promoter
Piotr Szymczyk, Grażyna Szymańska, Łukasz Kuźma, Agnieszka Jeleń, Ewa Balcerczak   +4 more
doaj   +1 more source

Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells

Biomedicines, 2021
Abnormal and excessive accumulation of lipid droplets within hepatic cells is the main feature of steatosis and nonalcoholic fatty liver disease (NAFLD) or metabolic-associated fatty liver disease (MAFLD).
Wan-Yun Gao, Pei-Yi Chen, Hao-Jen Hsu, Ching-Yen Lin, Ming-Jiuan Wu, Jui-Hung Yen   +5 more
doaj   +1 more source

Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway

Frontiers in Cell and Developmental Biology, 2022
Purpose: Osteoporosis, a common disorder especially prevalent in the postmenopausal women and the elderly, is becoming a worldwide public health problem.
Yanjun Wang, Lin Liu, Zechao Qu, Dong Wang, Wangli Huang, Lingbo Kong, Liang Yan   +6 more
doaj   +1 more source

The mechanisms of tanshinone in the treatment of tumors

Frontiers in Pharmacology, 2023
Tanshinone is a lipophilic compound that is present in traditional Chinese medicine and is derived from the roots of Salvia miltiorrhiza (Danshen). It has been proven to be highly effective in combating tumors in various parts of the body, including ...
Pengyu Zhang, Wendi Liu, Yuan Wang
doaj   +1 more source

Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction

Neural Regeneration Research, 2017
Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord
Yong-dong Yang, Xing Yu, Xiu-mei Wang, Xiao-hong Mu, Feng He   +4 more
doaj   +1 more source

SmDXS5, acting as a molecular valve, plays a key regulatory role in the primary and secondary metabolism of tanshinones in Salvia miltiorrhiza

Frontiers in Plant Science, 2022
Red sage, the dry root and rhizome of the herbaceous plant Salvia miltiorrhiza Bunge, is widely used for treating various diseases. The low content of tanshinones (terpenoids) has always restricted development of the S. miltiorrhiza industry.
Da-chuan Zhang, Ling-long Luo, Zhi-rong Wang, Wen-juan Xu, Jun-ling Li, Shu-ting Tan, Jia-hui Wu, Yan Li, Chi Zhang, Chen Liang, Xue-yong Wang   +10 more
doaj   +1 more source

Tanshinone Capsules Combined With Prednisone for Facial Seborrheic Dermatitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Frontiers in Medicine, 2022
BackgroundFacial seborrheic dermatitis (FSD), also called facial seborrheic eczema, is a common disease affecting both male and female patients worldwide.
Qiang Fu, Mengya Huang, Lei Tang, Qi Zheng, Fujun Huang, Xun Zhou, Xun Zhou, Shumei Wang   +7 more
doaj   +1 more source