Results 41 to 50 of about 11,335 (232)
Asian Journal of Pharmaceutical Sciences, 2017 Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge. Tanshinone IIA and cryptotanshinone are the major components in total tanshinones. However, the bioavailability of both compounds is low due to poor water solubility.
Zhai, Xifeng +4 more
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Journal of International Medical Research, 2019 Objective To investigate the cellular mechanisms of action of tanshinone IIA on the fatty liver disease induced by a high-fat diet in an animal model of non-alcoholic fatty liver disease (NAFLD).
Lu Huang +9 more
doaj +1 more source
Efficacy of tanshinone IIA in rat models with myocardial ischemia–reperfusion injury: a systematic mini-review and meta-analysis [PDF]
PeerJBackground Myocardial ischemia–reperfusion injury (MIRI) refers to severe damage to the ischemic myocardium following the restoration of blood flow, and it is a major complication of reperfusion therapy for myocardial infarction.
Xiaobin Zhang +9 more
doaj +2 more sources
Di-san junyi daxue xuebao, 2021 Objective To study the mechanism of lncRNA JPX targeting miR-378 in the proliferation, cloning and apoptosis of colon cancer SW620 cells induced by tanshinone ⅡA.
QIAN Jun +4 more
doaj +1 more source
Tanshinone I, tanshinone IIA, and cryptotanshinone: key bioactive components modulating vascular smooth muscle cell function. [PDF]
Front PharmacolCardiovascular diseases (CVDs) remain the leading cause of mortality among non-communicable diseases worldwide. Vascular smooth muscle cells (VSMCs), as the predominant cellular component of the tunica media, are essential for maintaining vascular homeostasis through phenotype-dependent regulation of vascular tone, blood pressure, and hemodynamics ...
Li J +8 more
europepmc +2 more sources
Genome-wide identification and characterization of Dof gene family in Salvia miltiorrhiza
Ornamental Plant ResearchSalvia miltiorrhiza is an important medicinal plant, and its main secondary metabolites are tanshinones and phenolic acids. Dof transcription factors play an irreplaceable role in regulating plant growth and secondary metabolism.
Xinyu Wang +5 more
doaj +1 more source
Studies on polynuclear furoquinones. Part 1: Synthesis of tri- and tetra-cyclic furoquinones simulating BCD/ABCD ring system of furoquinone diterpenoids [PDF]
, 2009 Synthesis of phenanthro[1,2-b]furan-10,11-dione, the core nucleus present in Tanshinone-I is described in 8–10 steps starting from 2-bromo-3,4-dihydro-1-naphthaldehyde. The bromoaldehyde was converted to methyl 2-(2-bromo-1-naphthyl)acetate or 2-(2-bromo-
Fang +8 more
core +1 more source
Tanshinone IIA: A Promising Natural Cardioprotective Agent [PDF]
Evidence-Based Complementary and Alternative Medicine, 2012 Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root ofSalvia miltiorrhizaBunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions.
Shang, Qinghua, Xu, Hao, Huang, Li
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Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats
Cellular Physiology and Biochemistry, 2018 Background/Aims: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a perennial plant also known as red sage used in traditional Chinese medicine. Tanshinone IIA has been shown to protect against various organ injuries.
Rulian Liang +6 more
doaj +1 more source
Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release [PDF]
, 2011 Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug ...
A Al-Omar +153 more
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