Results 21 to 30 of about 7,215 (115)

Identification of the Genome-Wide Expression Patterns of Non-Coding RNAs Associated with Tanshinones Synthesis Pathway in Salvia miltiorrhiza

Agronomy, 2023
The red root of Salvia miltiorrhiza Bunge, a famous traditional Chinese medicine (TCM), was caused by tanshinone in epidermis cells. In order to study the biological function of ncRNAs in the tanshinone synthesis, the expression patterns of mRNA and ...
Caicai Lin, Changhao Zhou, Zhongqian Liu, Xingfeng Li, Zhenqiao Song   +4 more
doaj   +1 more source

Genome-wide identification and characterization of Dof gene family in Salvia miltiorrhiza

Ornamental Plant Research
Salvia miltiorrhiza is an important medicinal plant, and its main secondary metabolites are tanshinones and phenolic acids. Dof transcription factors play an irreplaceable role in regulating plant growth and secondary metabolism.
Xinyu Wang, Qichao Wang, Siyu Hao, Jianjun Zhu, Guoyin Kai, Wei Zhou   +5 more
doaj   +1 more source

Efficacy of tanshinone IIA in rat models with myocardial ischemia–reperfusion injury: a systematic mini-review and meta-analysis [PDF]

PeerJ
Background Myocardial ischemia–reperfusion injury (MIRI) refers to severe damage to the ischemic myocardium following the restoration of blood flow, and it is a major complication of reperfusion therapy for myocardial infarction.
Xiaobin Zhang, Hehe Jiang, Linlin Zhang, Chen Chen, Mengzhen Xing, Dongqing Du, Yujie Li, Yuning Ma, Yuxia Ma, Chunjing Li   +9 more
doaj   +2 more sources

Tanshinone modulates the expression of Bcl-2 and Bax in cardiomyocytes and has a protective effect in a rat model of myocardial ischemia-reperfusion

Hellenic Journal of Cardiology, 2018
Objective: To investigate the protective activity of tanshinone in a rat model of myocardial ischemia-reperfusion and determine its effect on the expression of Bcl-2 and Bax in cardiomyocytes.
Rui Guo, Gen Li
doaj   +1 more source

Analysis and Identification of Active Compounds from Salviae miltiorrhizae Radix Toxic to HCT-116 Human Colon Cancer Cells

Applied Sciences, 2020
Colorectal cancer is one of the most frequently diagnosed cancers worldwide. The aim of the present study was to simultaneously analyze compounds of Salviae miltiorrhizae Radix (SMR) and determine their cytotoxic effects on HCT-116 human colorectal ...
Bohyung Kang, Sullim Lee, Chang-Seob Seo, Ki Sung Kang, You-Kyung Choi   +4 more
doaj   +1 more source

Tanshinone IIA ameliorates non-alcoholic fatty liver disease through targeting peroxisome proliferator-activated receptor gamma and toll-like receptor 4

Journal of International Medical Research, 2019
Objective To investigate the cellular mechanisms of action of tanshinone IIA on the fatty liver disease induced by a high-fat diet in an animal model of non-alcoholic fatty liver disease (NAFLD).
Lu Huang, Wei Ding, Ming-Qiang Wang, Zheng-Gen Wang, Hong-Hui Chen, Wen Chen, Qiong Yang, Ting-Na Lu, Qing Yang, Ji-Man He   +9 more
doaj   +1 more source

Tanshinone IIA Protects Against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-κB Pathway

Frontiers in Pharmacology, 2021
Tanshinone IIA, a fat-soluble diterpenoid isolated from Salvia miltiorrhiza Bunge, has been shown to attenuate the cerebral ischemic injury. The aim of this study was to examine the effects on neuroprotection and microglia activation of Tanshinone IIA ...
Zhibing Song, Zhibing Song, Jingjing Feng, Qian Zhang, Shanshan Deng, Dahai Yu, Yuefan Zhang, Tiejun Li   +7 more
doaj   +1 more source

Mechanism of lncRNA JPX targeting miR-378 in tanshinone ⅡA affecting proliferation, cloning and apoptosis in colon cancer SW620 cells

Di-san junyi daxue xuebao, 2021
Objective To study the mechanism of lncRNA JPX targeting miR-378 in the proliferation, cloning and apoptosis of colon cancer SW620 cells induced by tanshinone ⅡA.
QIAN Jun, CAO Yi, LI Lingchang, YU Jialin, HUO Jiege   +4 more
doaj   +1 more source

Tanshinone IIA attenuates the stemness of breast cancer cells via targeting the miR-125b/STARD13 axis

Experimental Hematology & Oncology, 2022
Background Tanshinone II A is an effective component extracted from Salvia miltiorrhiza and the roles of Tanshinone IIA in regulating the stemness of tumor cells remain unclear.
Xiaoman Li, Qi Jia, Yinyin Zhou, Xuan Jiang, Li Song, Yuanyuan Wu, Aiyun Wang, Wenxing Chen, Shijun Wang, Yin Lu   +9 more
doaj   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source