Results 1 to 10 of about 116,988 (242)

Renoprotective Effects of Tanshinone IIA: A Literature Review

Molecules, 2023
The kidney is an important organ in the human body, with functions such as urine production, the excretion of metabolic waste, the regulation of water, electrolyte and acid–base balance and endocrine release.
Chunguang Xie, Qianghua Yuan, Zhengtao Chen   +2 more
exaly   +5 more sources

Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling [PDF]

European Journal of Histochemistry
Tanshinone IIA is derived from Salvia miltiorrhiza and has multiple therapeutic targets and functions. The exact therapeutic effects on liver fibrosis as well as the underlying hepatoprotective mechanisms are still lacking.
Dan Wang, Qingquan Tan, Qing Zheng, Yanling Ma, Li Feng   +4 more
doaj   +3 more sources

Local Application of Tanshinone IIA protects mesenchymal stem cells from apoptosis and promotes fracture healing in ovariectomized mice

Journal of Orthopaedic Surgery and Research
Background Elderly patients suffering from osteoporotic fractures are more susceptible to delayed union or nonunion, and their bodies then are in a state of low-grade chronic inflammation with decreased antioxidant capacity. Tanshinone IIA is widely used
Shao Cheng, Xiaohui Hu, Kanghui Sun, Ziyu Huang, Yongjian Zhao, Yueli Sun, Bo Zeng, Jing Wang, Dongfeng Zhao, Sheng Lu, Qi Shi, Yongjun Wang, Weian Zhang, Xinhua Liu, Bing Shu   +14 more
doaj   +3 more sources

Pharmacological Effects and Mechanisms of Tanshinone IIA in Bone Injury Repair. [PDF]

Pharmaceuticals (Basel)
Tanshinone IIA (T-IIA), a fat-soluble diterpene quinone extracted from Salvia miltiorrhiza, is widely recognized for its multiple pharmacological properties, including anti-inflammatory, antioxidant, anti-fibrotic, and anti-tumor effects.
Hu W, Si Y, Wen X, Lin D, Yu Z, Xie X, Xu J.   +6 more
europepmc   +2 more sources

Local Sodium Tanshinone IIA Sulfonate Attenuates Periodontal Bone Loss by Modulating Inflammatory, Immune and Osteoclastogenic Signalling. [PDF]

J Clin Periodontol
ABSTRACT Aim To investigate whether local administration of sodium tanshinone IIA sulfonate (STS) modulates periodontal inflammation, alveolar bone loss, immune response and bone remodelling–related signalling pathways in a ligature‐induced murine model of periodontitis.
de Molon RS, Scarel-Caminaga RM, Caldeira FID, Ervolino E, de Avila ED, Barbugli PA, Oliveira GE, Franco-Moura JP, Theodoro LH, Cirelli JA, Tetradis S, Kantarci A.   +11 more
europepmc   +2 more sources

Tanshinone IIA induces ferroptosis in colorectal cancer cells through the suppression of SLC7A11 expression via the PI3K/AKT/mTOR pathway. [PDF]

Eur J Med Res
Colorectal cancer (CRC) is a malignant tumor of the digestive system with high incidence rate and mortality. Tanshinone IIA (Tan IIA) plays an anti-cancer role in a variety of cancer cells.
Ge T, Li H, Xiang P, Yang D, Zhou J, Zhang Y.   +5 more
europepmc   +2 more sources

Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis

Mediators of Inflammation
Background. Cerebral ischemia–reperfusion injury is a common complication of ischemic stroke that affects the prognosis of patients with ischemic stroke.
Wenbing Su, Meifen Lv, Dayu Wang, Yinghong He, Hui Han, Yu Zhang, Xiuying Zhang, Shaokun Lv, Liqing Yao   +8 more
doaj   +2 more sources

Tanshinone IIA attenuates psoriasis via Nrf2/HO-1 activation: Mechanistic insights from preclinical models [PDF]

Biochemistry and Biophysics Reports
Background: Psoriasis is a chronic inflammatory skin disorder driven by oxidative stress and immune dysregulation. Tanshinone IIA, a bioactive compound from Salvia miltiorrhiza, exhibits antioxidant properties, but its role in treating psoriasis remains ...
Xia Xu, Jingyao Liang, Maofang Huang, Quan Chen, Shijian Xiang, Xianhua Tang, Zhang Jingyue   +6 more
doaj   +2 more sources

Plant Compounds Inhibit the Growth of W12 Cervical Precancer Cells Containing Episomal or Integrant HPV DNA; Tanshinone IIA Synergizes with Curcumin in Cervical Cancer Cells

Viruses
This study explores the effects of plant compounds on human papillomavirus (HPV)-induced W12 cervical precancer cells and bioelectric signaling. The aim is to identify effective phytochemicals, both individually and in combination, that can prevent and ...
Linda Saxe Einbond, Jing Zhou, Kunhui Huang, Mario R. Castellanos, Emeka Mbazor, Michael Balick, Hongbao Ma, James A. DeVoti, Stephen Redenti, Hsan-au Wu   +9 more
doaj   +2 more sources

Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation

Pharmaceutical Biology, 2021
Context Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain.
Lijie Liu, Hanjing Gao, Tao Wen, Tao Gu, Shuang Zhang, Zhiyong Yuan   +5 more
doaj   +1 more source