Tanshinone IIA inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via Akt/Skp2/p27-associated pathway. [PDF]
PLoS ONE, 2013 We previously showed that tanshinone IIA ameliorated the hypoxia-induced pulmonary hypertension (HPH) partially by attenuating pulmonary artery remodeling.
Ying Luo +7 more
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Preclinical and clinical examinations of
, 2006 Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina ...
Lien Eric +3 more
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Tanshinone IIA protects against dopaminergic neuron degeneration via regulation of DJ-1 and Nrf2/HO-1 pathways in a rodent model of Parkinson’s disease [PDF]
, 2021 Purpose: To study the potential neuroprotective effects of tanshinone IIA, a diterpene quinone, in an experimental model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD).
Ji, Xingwang +3 more
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Experimental Hematology & Oncology, 2022 Background Tanshinone II A is an effective component extracted from Salvia miltiorrhiza and the roles of Tanshinone IIA in regulating the stemness of tumor cells remain unclear.
Xiaoman Li +9 more
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Expression of P53 and Bcl2 Mammary Adenocarcinoma in C3H Mice Administered with Salvia Miltiorrhizae Bunge Root Extract [PDF]
, 2016 BackgroundBreast cancer is on the first or second most Malignancy in many places around the world. The incidence of breast cancer was increasing, also in Indonesia.
Dewi, L. S. (Liza) +2 more
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Cryptotanshinone but not tanshinone IIA inhibits angiogenesis in vitro [PDF]
Experimental & Molecular Medicine, 2005 In the course of screening of angiogenesis inhibitor from natural products, cryptotanshinone from Salvia miltiorrhiza was isolated as a potent small molecule inhibitor of angiogenesis. Cryptotanshinone inhibits bFGF-induced angiogenesis of BAECs at ten micromolar ranges in vitro without cytotoxicity.
Jong Moon, Hur +3 more
openaire +2 more sources
Combining Metabolomics and Transcriptomics to Characterize Tanshinone Biosynthesis in Salvia Miltiorrhiza [PDF]
, 2014 Plant natural products have been co-opted for millennia by humans for various uses such as flavor, fragrances, and medicines. These compounds often are only produced in relatively low amounts and are difficult to chemically synthesize, limiting access ...
Cui, Guanghong +12 more
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Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy [PDF]
, 2014 published_or_final_versio
CHEUNG, F +7 more
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Counter-current chromatography for the separation of terpenoids: A comprehensive review with respect to the solvent systems employed [PDF]
, 2014 Copyright @ 2014 The Authors.This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.Natural ...
A Berthod +172 more
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Cell Death Discovery, 2023 The inhibitor of apoptosis protein survivin has a critical regulatory role in carcinogenesis and treatment tolerance in colorectal cancer (CRC). However, the targeted drugs for survivin protein are extremely limited.
Yaoquan Cao +10 more
semanticscholar +1 more source