Results 21 to 30 of about 79,005 (262)

Tanshinone IIA Stimulates Erythrocyte Phosphatidylserine Exposure [PDF]

Cellular Physiology and Biochemistry, 2012
Tanshinone IIA, an antimicrobial, antioxidant, antianaphylactic, antifibrotic, vasodilating, antiatherosclerotic, organo-protective and antineoplastic component from the rhizome of Salvia miltiorrhiza, is known to trigger apoptosis of tumor cells. Tanshinone IIA is effective in part through mitochondrial depolarization and altered gene expression ...
ZELENAK C., PASHAM V., JILANI K., TRIPODI P.M., ROSACLERIO L., PATHARE G., LUPESCU A., FAGGIO, Caterina, QADRI S.M., LANG F.   +9 more
openaire   +5 more sources

Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells. [PDF]

PLoS ONE, 2016
Tanshinone IIA, one of the most pharmacologically bioactive phytochemicals isolated from Salvia miltiorrhiza Bunge, possesses several biological activities such as anti-inflammation, anti-cancer, neuroprotection and hypolipidemic activities.
Hung-Chen Chen, Pei-Yi Chen, Ming-Jiuan Wu, Mi-Hsueh Tai, Jui-Hung Yen   +4 more
doaj   +1 more source

Investigation of the mechanism of tanshinone IIA to improve cognitive function via synaptic plasticity in epileptic rats

Pharmaceutical Biology, 2023
Context Tanshinone IIA is an extract of Salvia miltiorrhiza Bunge (Labiatae) used to treat cardiovascular disorders. It shows potential anticonvulsant and cognition-protective properties.Objective We investigated the mechanism of tanshinone IIA on ...
Chen Jia, Rui Zhang, Liming Wei, Jiao Xie, Suqin Zhou, Wen Yin, Xi Hua, Nan Xiao, Meile Ma, Haisheng Jiao   +9 more
doaj   +1 more source

Nano-encapsulated tanshinone IIA in PLGA-PEG-COOH inhibits apoptosis and inflammation in cerebral ischemia/reperfusion injury

Green Processing and Synthesis, 2023
Tanshinone IIA has a potential therapeutic effect on cerebral ischemia/reperfusion injury (CIRI). In this study, tanshinone IIA was encapsulated in poly(lactic-co-glycolic acid)-block-poly (ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) nanoparticles ...
Zhang Xin, Zhu Xutong, Huang Lifa, Chen Zupeng, Wang Yuchen, Liu Yajun, Pan Ruihan, Lv Ling   +7 more
doaj   +1 more source

Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells

Biomedicines, 2021
Abnormal and excessive accumulation of lipid droplets within hepatic cells is the main feature of steatosis and nonalcoholic fatty liver disease (NAFLD) or metabolic-associated fatty liver disease (MAFLD).
Wan-Yun Gao, Pei-Yi Chen, Hao-Jen Hsu, Ching-Yen Lin, Ming-Jiuan Wu, Jui-Hung Yen   +5 more
doaj   +1 more source

Tanshinone IIA changed the amniotic fluid volume and regulated expression of AQP1 and AQP3 in amniotic epithelium cells: a promising drug treating abnormal amniotic fluid volume

Molecular Medicine, 2023
Background Many studies have confirmed the association of aquaporins (AQPs) with abnormal amniotic fluid volume (AFV). In our previous experiments, we found that Tanshinone IIA was able to regulate the expression of AQP1 and AQP3.
Shuangjia Pan, Yehui Lan, Baoyi Chen, Yujia Zhou, Xinxin Ying, Ying Hua   +5 more
doaj   +1 more source

Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion

Frontiers in Bioscience, 2012
Tanshinone IIA (Tan IIA), an active component derived from Salvia miltiorrhiza root, has been used to treat various ischemic cardiovascular and cerebrovascular diseases. However, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. Here, we addressed this issue by using a 90-minute partial liver ischemia model.
Yan-yan, Qi, Liang, Xiao, Lu-ding, Zhang, Shao-hua, Song, Yi, Mei, Teng, Chen, Jian-ming, Tang, Fang, Liu, Guo-shan, Ding, Yong-zhao, Shi, Quan-xing, Wang   +10 more
openaire   +3 more sources

Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake [PDF]

Biochemical Pharmacology, 2012
Our seminal discovery of high mobility group box 1 (HMGB1) as a late mediator of lethal systemic inflammation has prompted a new field of investigation for the development of experimental therapeutics. We previously reported that a major Danshen ingredient, tanshinone IIA sodium sulfonate (TSN-SS), selectively inhibited endotoxin-induced HMGB1 release ...
Yusong, Zhang, Wei, Li, Shu, Zhu, Arvin, Jundoria, Jianhua, Li, Huan, Yang, Saijun, Fan, Ping, Wang, Kevin J, Tracey, Andrew E, Sama, Haichao, Wang   +10 more
openaire   +2 more sources

Tanshinone IIA Has a Potential Therapeutic Effect on Kawasaki Disease and Suppresses Megakaryocytes in Rabbits With Immune Vasculitis

Frontiers in Cardiovascular Medicine, 2022
Background and ObjectiveIt is urgent to find out an alternative therapy for Kawasaki disease (KD) since around 20% patients are resistant to intravenous immunoglobulin (IVIG) or aspirin.
Hui Chen, Huiying Shu, Weiqing Su, Bo Li, Bo Li, Hua Zhang, Liang Li, Chao Lin, Wenfang Yi, Xiao-Yong Zhan, Chun Chen, Xiaojing Li, Yanqi Yang, Min Zhou, Mo Yang, Mo Yang   +15 more
doaj   +1 more source

Tanshinone IIA Protects Against Cerebral Ischemia Reperfusion Injury by Regulating Microglial Activation and Polarization via NF-κB Pathway

Frontiers in Pharmacology, 2021
Tanshinone IIA, a fat-soluble diterpenoid isolated from Salvia miltiorrhiza Bunge, has been shown to attenuate the cerebral ischemic injury. The aim of this study was to examine the effects on neuroprotection and microglia activation of Tanshinone IIA ...
Zhibing Song, Zhibing Song, Jingjing Feng, Qian Zhang, Shanshan Deng, Dahai Yu, Yuefan Zhang, Tiejun Li   +7 more
doaj   +1 more source