Results 31 to 40 of about 79,005 (262)

Tanshinone IIA enhances the therapeutic efficacy of mesenchymal stem cells derived exosomes in myocardial ischemia/reperfusion injury via up-regulating miR-223-5p.

Journal of Controlled Release, 2023
Myocardial ischemia-reperfusion injury (MI/RI) is a serious obstacle for patients with coronary heart disease (CHD) to benefit from post-ischemic reflow.
Sheng Li, Ke Yang, W. Cao, Rui Guo, Zhihao Liu, Jing Zhang, Aodi Fan, Yuting Huang, Chuanrui Ma, Lan Li, Guanwei Fan   +10 more
semanticscholar   +1 more source

Tanshinone IIA confers protection against myocardial ischemia/reperfusion injury by inhibiting ferroptosis and apoptosis via VDAC1

International Journal of Molecular Medicine, 2023
Tanshinone IIA (TSN) extracted from danshen (Salvia miltiorrhiza) could protect cardiomyocytes against myocardial ischemia/reperfusion injury (IRI), however the underlying molecular mechanisms of action remain unclear. The aim of the present study was to
Tie Hu, Hua-Xi Zou, Shu-Yu Le, Ya-ru Wang, Yang Qiao, Yong Yuan, Ji-chun Liu, Song-Qing Lai, Huang Huang   +8 more
semanticscholar   +1 more source

PPARG is a potential target of Tanshinone IIA in prostate cancer treatment: a combination study of molecular docking and dynamic simulation based on transcriptomic bioinformatics

European Journal of Medical Research, 2023
Tanshinone IIA is a lipophilic organic compound from the root of Danshen (Salvia miltiorrhiza) and is one of the most well-known Tanshinone molecules by pharmacologists.
Tongtong Zhang, Xinglin Chen, Xiran Ju, Jixiang Yuan, Jielong Zhou, Zhihang Zhang, Guanqun Ju, Dongliang Xu   +7 more
doaj   +1 more source

Tanshinone IIA mediates protection from diabetes kidney disease by inhibiting oxidative stress induced pyroptosis.

Journal of Ethnopharmacology, 2023
ETHNOPHARMACOLOGICAL RELEVANCE Salvia miltiorrhiza is widely used traditional Chinese medicine in the treatment of diabetes kidney disease (DKD). Tanshinone IIA (Tan IIA) are one of the main components of the root of red-rooted Salvia miltiorrhiza Bunge.
Q. Wu, Yu-bo Guan, Ke-jia Zhang, Li Li, Yao Zhou   +4 more
semanticscholar   +1 more source

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism [PDF]

, 2014
Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to bring about healing without increasing susceptibility to infection.
Anderson, S.R., Bojarczuk, A.N., Burgon, J., Chimen, M., Coles, M.C., Farrow, S.N., Hamza, B., Holmes, G.R., Irimia, D., Jones, S., Kadirkamanathan, V., Loynes, C.A., Prince, L.R., Rainger, G.E., Renshaw, S.A., Robertson, A.L., Sawtell, A.K., Solari, R., Walmsley, S.R., Whyte, M.K.B., Willson, J.   +20 more
core   +1 more source

Endophyte Chaetomium globosum D38 Promotes Bioactive Constituents Accumulation and Root Production in Salvia miltiorrhiza [PDF]

, 2018
Salvia miltiorrhiza is known for tanshinones and salvianolic acids, which have been shown to have a protective effect against ROS, especially for cardiovascular diseases and other various ailments of human organs.
Han, T, Ji, J, Jia, M, Kong, Z, Li, X, Luo, D, Qin, L, Rahman, K, Zhai, X, Zheng, C   +9 more
core   +3 more sources

Tanshinone IIA: a Chinese herbal ingredient for the treatment of atherosclerosis

Frontiers in Pharmacology, 2023
Tanshinone IIA (Tan IIA) is a fat-soluble compound extracted from Salvia miltiorrhiza, which has a protective effect against atherosclerosis (AS). Tan IIA can inhibit oxidative stress and inflammatory damage of vascular endothelial cells (VECs) and ...
Chunkun Yang, Yanguang Mu, Shuanghong Li, Yang Zhang, Xiaoyuan Liu, Jun Li   +5 more
semanticscholar   +1 more source

Tanshinone Iia Inhibits Megakaryopoiesis in Immune Vasculitis

Blood, 2021
Abstract Introduction Tanshinone IIA, an active component of Danshen (Salvia miltiorrhiza), has been used for centuries to treat hypercoagulation-related diseases, which attributed to its anti-platelet and anti-inflammatory effects. However, the role of Tanshinone IIA in megakaryocytes, the precursor of platelet within the bone marrow ...
Hui Chen, Min Zhou, Huiying Shu, Weiqing Su, Liuming Yang, Liang Li, Beng H Chong, Mo Yang   +7 more
openaire   +1 more source

Tanshinone IIA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction

Neural Regeneration Research, 2017
Tanshinone IIA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone IIA 20 mg/kg into rat models of spinal cord
Yong-dong Yang, Xing Yu, Xiu-mei Wang, Xiao-hong Mu, Feng He   +4 more
doaj   +1 more source

Analysis and Identification of Active Compounds from Salviae miltiorrhizae Radix Toxic to HCT-116 Human Colon Cancer Cells

Applied Sciences, 2020
Colorectal cancer is one of the most frequently diagnosed cancers worldwide. The aim of the present study was to simultaneously analyze compounds of Salviae miltiorrhizae Radix (SMR) and determine their cytotoxic effects on HCT-116 human colorectal ...
Bohyung Kang, Sullim Lee, Chang-Seob Seo, Ki Sung Kang, You-Kyung Choi   +4 more
doaj   +1 more source