Results 61 to 70 of about 116,988 (242)

Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1

Phytotherapy Research, 2023
Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism is a critical factor that affects the occurrence and ...
Shun Wu, Dingchun Lu, Babu Gajendran, Qi-Lan Hu, Jian Zhang, Sheng-Quan Wang, Minzhen Han, Yi-Ni Xu, Xiangchun Shen   +8 more
semanticscholar   +1 more source

Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6

, 2009
Tanshinone IIa, the primary active component of a traditional Chinese medicine Salvia miltiorrhiza (Danshen), has a wide range of pharmacological activities.
Hu, Y., Li, W., 杨凌, He, Y. -Q., Liu, Y., Yang, L., Liu, H. -X.   +6 more
core   +1 more source

Tanshinone IIA suppress the proliferation of HNE-1 nasopharyngeal carcinoma an in vitro study [PDF]

, 2016
Nasopharyngeal carcinoma (NPC) at present is considered to be one of the fatal diseases detected commonly in the people belonging to Southeast Asia and southern China.
Zhou, Mingguang, Hu, SunHong, Zhou, Guojin, Zhang, Lei   +3 more
core   +1 more source

Tanshinone Iia Inhibits Megakaryopoiesis in Immune Vasculitis

Blood, 2021
Abstract Introduction Tanshinone IIA, an active component of Danshen (Salvia miltiorrhiza), has been used for centuries to treat hypercoagulation-related diseases, which attributed to its anti-platelet and anti-inflammatory effects. However, the role of Tanshinone IIA in megakaryocytes, the precursor of platelet within the bone marrow ...
Hui Chen, Min Zhou, Huiying Shu, Weiqing Su, Liuming Yang, Liang Li, Beng H Chong, Mo Yang   +7 more
openaire   +1 more source

Progress of tanshinone IIA against respiratory diseases: therapeutic targets and potential mechanisms [PDF]

Frontiers in Pharmacology
Zhaohui Ding
exaly   +2 more sources

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Tanshinone IIA Ameliorates Myocardial Ischemia–Reperfusion Injury via Activating HDAC1‐Repressed Nrf2‐xCT/Gpx4/HO‐1 Axis

Chemical Biology and Drug Design
Myocardial ischemia/reperfusion injury (MIRI) brings secondary injury to heart tissues and involves complicated pathophysiological activities, such as cell death, oxidative stress, and inflammation.
Ke Yan, Shenghui Yu, Xiang Gao, Lei Li, Li Ding   +4 more
semanticscholar   +1 more source

Tanshinone IIA alleviates atherosclerosis in LDLR−/− mice by regulating efferocytosis of macrophages

Frontiers in Pharmacology, 2023
Background: Tanshinone IIA (TIIA) is the major lipid-soluble active ingredient of the traditional Chinese medicine Salvia miltiorrhiza, which slows down atherosclerosis (AS).
Jia-Rou Wang, Yifan Zhang, Xiao-Teng Feng, Min Du, Sijin Li, Xindi Chang, Ping Liu   +6 more
semanticscholar   +1 more source

Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion

Frontiers in Bioscience, 2012
Tanshinone IIA (Tan IIA), an active component derived from Salvia miltiorrhiza root, has been used to treat various ischemic cardiovascular and cerebrovascular diseases. However, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. Here, we addressed this issue by using a 90-minute partial liver ischemia model.
Yan-yan, Qi, Liang, Xiao, Lu-ding, Zhang, Shao-hua, Song, Yi, Mei, Teng, Chen, Jian-ming, Tang, Fang, Liu, Guo-shan, Ding, Yong-zhao, Shi, Quan-xing, Wang   +10 more
openaire   +2 more sources

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source