Results 61 to 70 of about 79,005 (262)

Tanshinone IIA ameliorates non-alcoholic fatty liver disease through targeting peroxisome proliferator-activated receptor gamma and toll-like receptor 4

Journal of International Medical Research, 2019
Objective To investigate the cellular mechanisms of action of tanshinone IIA on the fatty liver disease induced by a high-fat diet in an animal model of non-alcoholic fatty liver disease (NAFLD).
Lu Huang, Wei Ding, Ming-Qiang Wang, Zheng-Gen Wang, Hong-Hui Chen, Wen Chen, Qiong Yang, Ting-Na Lu, Qing Yang, Ji-Man He   +9 more
doaj   +1 more source

Tanshinone IIA Attenuates Contrast-Induced Nephropathy via Nrf2 Activation in Rats

Cellular Physiology and Biochemistry, 2018
Background/Aims: Tanshinone IIA is a chemical compound extracted from Salvia miltiorrhiza Bunge, a perennial plant also known as red sage used in traditional Chinese medicine. Tanshinone IIA has been shown to protect against various organ injuries.
Rulian Liang, Qing Zhao, Guihua Jian, Dongsheng Cheng, Niansong Wang, Guangyuan Zhang, Feng Wang   +6 more
doaj   +1 more source

Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies [PDF]

, 2018
L
Balla, György, Barta, Tünde, Haines, David Donald, Lekli, István, Tósaki, Ágnes, Tósaki, Árpád   +5 more
core   +1 more source

Tanshinone IIA promotes vascular normalization and boosts Sorafenib’s anti-hepatoma activity via modulating the PI3K-AKT pathway

Frontiers in Pharmacology, 2023
Introduction: Angiogenesis is an essential feature of liver cancer. Tumor hypoxia results from abnormal vessel architecture. Numerous studies have sufficiently demonstrated that Tanshinone IIA (Tan IIA) can increase blood flow and enhance ...
Chengdong Qin, Siyuan Liu, Shiqi Zhou, Xianghou Xia, Jiejie Hu, Yang Yu, D. Ma   +6 more
semanticscholar   +1 more source

Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats

Molecular Medicine Reports, 2016
Multiple sclerosis (MS) is an inflammatory autoimmune neurodegenerative disease, which features focal demyelination and inflammatory cell infiltration of the brain and the spinal cord. Tanshinone IIA (TSIIA), one of the major fat‑soluble components of Salvia miltiorrhiza (Danshen), has anti‑inflammatory, immunoregulatory and neuroprotective activity ...
Yan, Jun, Yang, Xue, Han, Dong, Feng, Juan   +3 more
openaire   +3 more sources

Tanshinone IIA alleviates atherosclerosis in LDLR−/− mice by regulating efferocytosis of macrophages

Frontiers in Pharmacology, 2023
Background: Tanshinone IIA (TIIA) is the major lipid-soluble active ingredient of the traditional Chinese medicine Salvia miltiorrhiza, which slows down atherosclerosis (AS).
Jiarou Wang, Yifan Zhang, Xiaoteng Feng, Min Du, Sijin Li, Xindi Chang, Ping Liu   +6 more
semanticscholar   +1 more source

Tanshinone IIA delays liver aging by modulating oxidative stress. [PDF]

Front Pharmacol
Organ-specific aging is increasingly recognized for its research significance, with liver aging demonstrating particular relevance due to its central role in metabolism. We have pioneered the discovery that the expression of ESRRG in the liver positively correlates with age and have established its association with clinical characteristics, including ...
Liu Q, Li X, Luo Y.
europepmc   +4 more sources

Tanshinone IIA ameliorates Aβ transendothelial transportation through SIRT1-mediated endoplasmic reticulum stress

Journal of Translational Medicine, 2023
Background The disruption of blood-brain barrier (BBB), predominantly made up by brain microvascular endothelial cells (BMECs), is one of the characteristics of Alzheimer’s disease (AD).
Can Wan, Xiao-qi Liu, Mei Chen, Hui Ma, Guangping Wu, Lijun Qiao, Ye-Feng Cai, Shi-Jie Zhang   +7 more
semanticscholar   +1 more source

Evaluation of Tanshinone IIA Developmental Toxicity in Zebrafish Embryos [PDF]

Molecules, 2017
Tanshinone IIA (Tan-IIA) is derived from the dried roots of Salvia miltiorrhiza Bunge, a traditional Chinese medicine. Although Salvia miltiorrhiza has been applied for many years, the toxicity of the mono-constituent of Salvia miltiorrhiza, tanshinone IIA, is still understudied.
Tao Wang, Chengxi Wang, Qiong Wu, Kangdi Zheng, Jiaojiao Chen, Yutao Lan, Yao Qin, Wenjie Mei, Baoguo Wang   +8 more
openaire   +3 more sources

Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation

Acta Cirúrgica Brasileira, 2022
Purpose: Tanshinone IIA is a well-known lipophilic active constituent refined from traditional Chinese medicines, danshen. It has been previously demonstrated to possess various biological properties, including anti-inflammatory, antioxidant, promoting ...
Dan Li, Zhihui Yang, Shan Gao, Hao Zhang, Guanwei Fan   +4 more
doaj   +1 more source