Results 81 to 90 of about 116,988 (242)

Influence of Tanshinone IIA on the Apoptosis of Human Esophageal Ec-109 Cells

Natural Product Communications, 2016
The induced-apoptosis effect and mechanism of human esophageal cancer Ec-109 cells via tanshinone IIA was investigated. The Ec-109 cells were cultured in vitro with different concentrations of tanshinone IIA (2 μg/mL, 4 μg/mL, or 8 μg/mL) for 12, 24, 36,
Yan-Qin Zhu, Bai-Yan Wang, Fang Wu, Yong-Kang An, Xin-Qiang Zhou   +4 more
doaj   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

Smart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia–reperfusion injury by inhibiting the STING pathway

Chinese Medicine
Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge and Salvia miltiorrhiza Bunge, respectively, both of which have been employed in the treatment of ...
Pan Zhai, Qianyun Chen, Xun-Xun Wang, Xiao-Hu S. Ouyang, Mengling Yang, Yalan Dong, Jun-Yi Li, Yiming Li, Shan-Shan Luo, Yue Liu, Xiang Cheng, Rui Zhu, Desheng Hu   +12 more
semanticscholar   +1 more source

Bushen Huatan Formula Ameliorates Early Chronic Low‐Grade Inflammation in Obese PCOS Via the TLR4/NF‐κB Signaling Pathway: An Integrated Network Pharmacology and Experimental Study

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Objective This study used an integrated network pharmacology and experimental strategy to investigate how Bushen Huatan Formula (BHF) mitigates early‐stage chronic low‐grade inflammation in obese polycystic ovary syndrome (PCOS). Methods Candidate components and targets of BHF were retrieved from the TCMSP database, and protein–protein ...
Jianing Zhang, Fangyun Gu, Yunyun Li, Xiaoling Feng, Hongying Kuang, Fang Xu, Miao Sun   +6 more
wiley   +1 more source

Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual‐like protein 1 and acyl‐coenzyme A synthetase long‐chain family member 4 signaling pathway

Journal of Diabetes Investigation
Tanshinone IIA (TIIA) is one of the main components of the root of the red‐rooted Salvia miltiorrhiza Bunge. However, the molecular mechanisms underlying TIIA‐mediated protective effects in diabetic nephropathy (DN) are still unclear.
Shuai Zhu, Zhiqiang Kang, Fengjiao Zhang
semanticscholar   +1 more source

Tanshinone IIA effects on ovarian cancer cell line

Journal of Pharmacy and Pharmacology, 2018
Abstract Objectives To explore the potential therapeutic effect of Tanshinone IIA against ovarian cancer in vitro and elucidate the underlying molecular mechanism. Methods The cell survival upon Tanshinone IIA treatment was determined
Nan Li, Liang Yang, Baolian Zhang, Suqin Chen   +3 more
openaire   +2 more sources

Alcoholic extracts of Russian sage (Salvia yangii) contain bioactive terpenoids with inhibitory activity against grapevine downy mildew (Plasmopara viticola)

Pest Management Science, Volume 82, Issue 9, Page 8159-8170, September 2026.
Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone, Oscar Giovannini, Martina Magni, Michael Oberhuber, Peter Robatscher, Michele Perazzolli   +5 more
wiley   +1 more source

Cortical Organoid-on-a-Chip with Physiological Hypoxia for Investigating Tanshinone IIA-Induced Neural Differentiation

Research, 2023
Cortical organoids represent cutting-edge models for mimic human brain development during the early and even middle stage of pregnancy, while they often fail to recreate the complex microenvironmental factors, such as physiological hypoxia.
Yue Zhi, Yujuan Zhu, Jing-Lin Wang, Junqi Zhao, Yuanjin Zhao   +4 more
semanticscholar   +1 more source

Tanshinone IIA Protects Against Cardiac Hypertrophy via Inhibiting Calcineurin/Nfatc3 Pathway

International Journal of Biological Sciences, 2011
Pathological cardiac hypertrophy induced by adrenergic overactivation can subsequently develop to heart failure which remains as a leading cause of mortality worldwide.
Xueying Tan, Jianping Li, Xinyue Wang, Nan Chen, Benzhi Cai, Gang Wang, Hongli Shan, Deli Dong, Yanju Liu, Xingda Li, Fan Yang, Xin Li, Peng Zhang, Xueqi Li, Baofeng Yang, Yanjie Lu
doaj  

Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization

Journal of Hematology & Oncology, 2012
Background Promotion of endothelial normalization restores tumor oxygenation and obstructs tumor cells invasion, intravasation, and metastasis. We therefore investigated whether a vasoactive drug, tanshinone IIA, could inhibit metastasis by inducing ...
Wang Wen-Quan, Liu Liang, Sun Hui-Chuan, Fu Yan-Ling, Xu Hua-Xiang, Chai Zong-Tao, Zhang Qiang-Bo, Kong Ling-Qun, Zhu Xiao-Dong, Lu Lu, Ren Zheng-Gang, Tang Zhao-You   +11 more
doaj   +1 more source