Results 81 to 90 of about 79,005 (262)

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Herb Target Prediction Based on Representation Learning of Symptom related Heterogeneous Network. [PDF]

, 2019
Traditional Chinese Medicine (TCM) has received increasing attention as a complementary approach or alternative to modern medicine. However, experimental methods for identifying novel targets of TCM herbs heavily relied on the current available herb ...
Chen, Jianxin, Gao, Zhuye, Hu, Xiaochen, Li, Peng, Liu, Baoyan, Peng, Yonghong, Wang, Ning, Xu, Hao, Yang, Kuo, Zhang, Runshun, Zhou, Xuezhong, Zhu, Qiang   +11 more
core   +1 more source

The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia–reperfusion injury by inhibiting the STING pathway

Chinese Medicine
Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge and Salvia miltiorrhiza Bunge, respectively, both of which have been employed in the treatment of ...
Pan Zhai, Qianyun Chen, Xunxun Wang, Xiaohu Ouyang, Mengling Yang, Yalan Dong, Junyi Li, Yiming Li, Shanshan Luo, Yue Liu, Xiang Cheng, Rui Zhu, Desheng Hu   +12 more
semanticscholar   +1 more source

Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation

Chinese Medicine, 2023
Rheumatoid arthritis (RA) is characterized by bone destruction in the afflicted joints, and during the process of bone destruction, osteoclasts play a crucial role. Tanshinone IIA (Tan IIA) has shown anti-inflammatory effects in RA.
Qiu-wei Peng, Jian Wang, Man Han, Minghong Zhao, Kesong Li, Tianming Lu, Qiuyan Guo, Quan Jiang   +7 more
semanticscholar   +1 more source

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Tanshinone IIA attenuates atherosclerosis via inhibiting NLRP3 inflammasome activation

Aging, 2020
Tanshinone IIA (Tan IIA) possesses potent anti-atherogenic function, however, the underlying pharmacological mechanism remains incompletely understood. Previous studies suggest that oxidized LDL (oxLDL)-induced NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) inflammasome activation in macrophages plays a vital role in ...
Wen, Jiexia, Chang, Yumei, Huo, Shanshan, Li, Wenyan, Huang, Heling, Gao, Yunhuan, Lin, Hongyu, Zhang, Jianlou, Zhang, Yonghong, Zuo, Yuzhu, Cao, Xuebin, Zhong, Fei   +11 more
openaire   +2 more sources

Tanshinone IIA Selectively Enhances Hyperpolarization-Activated Cyclic Nucleotide–Modulated (HCN) Channel Instantaneous Current

Journal of Pharmacological Sciences, 2009
.: Tanshinone IIA, one of the main active components from the Chinese herb Danshen, is widely used to treat cardiovascular diseases in Asian countries, especially in China.
Qiansheng Liang, Le Yang, Zhaohua Wang, Sufang Huang, Shusheng Li, Guangtian Yang   +5 more
doaj   +1 more source

Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine [PDF]

, 2016
published_or_final_versio
Chan, SW, Cui, G, Hoi, MPM, Kwan, YW, Lee, SMY, Leung, GPH, Tseng, HHL, Zhou, X   +7 more
core   +1 more source

Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual‐like protein 1 and acyl‐coenzyme A synthetase long‐chain family member 4 signaling pathway

Journal of Diabetes Investigation
Tanshinone IIA (TIIA) is one of the main components of the root of the red‐rooted Salvia miltiorrhiza Bunge. However, the molecular mechanisms underlying TIIA‐mediated protective effects in diabetic nephropathy (DN) are still unclear.
Shuai Zhu, Zhiqiang Kang, Fengjiao Zhang
semanticscholar   +1 more source

Tanshinone ⅡA participates in the treatment of endometriosis by regulating adhesion, invasion, angiogenesis and inhibition of PI3K/Akt/mTOR signaling pathway

Molecular Medicine Reports, 2023
Endometriosis (EMs) is a common gynecological disorder characterized by abnormal growth of the endometrial stroma and glands outside the uterus. Tanshinone IIA, the active component of Chinese medicine Danshen (Salvia miltiorrhiza Bge.), has a number of ...
Xiaoxiao Zhang, Shumiao Li, Zhenzhen Chen, Wei Liang, Shuting Pei, Feiyue Gou, Zhicheng Jia, Zhaoyang Geng, Xin Gong   +8 more
semanticscholar   +1 more source